Results 51 to 60 of about 101,823 (276)

Quality of life with ivabradine in patients with angina pectoris [PDF]

, 2016
Background—To explore the effect of ivabradine on angina-related quality of life (QoL) in patients participating in the Study Assessing the Morbidity–Mortality Benefits of the If Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) QoL
Chassany, Olivier, Ferrari, Roberto, Ford, Ian, Fox, Kim, Steg, Philippe Gabriel, Tardif, Jean-Claude, Tendera, Michal   +6 more
core   +1 more source

De-risking primary prevention: role of imaging

Therapeutic Advances in Cardiovascular Disease, 2021
Atherosclerotic cardiovascular disease (ASCVD) is a common disease among the general population, and includes four major areas: (1) coronary heart disease (CHD), manifested by stable angina, unstable angina, myocardial infarction (MI), heart failure, and
Ahmed M. Shafter, Kashif Shaikh, Amit Johanis, Matthew J. Budoff   +3 more
doaj   +1 more source

Evaluating the Implications of a Coronary Artery Calcium Score of Zero (CAC = 0) in Modern Risk Prediction: Is Zero Truly Zero? [PDF]

Cureus
Dos Santos Pereira SI, Venugopal A, Manoukian G, Ilahi HB, Masood MH, Abdulrahman Shembesh MS, Anan A, Sufwan N, Sandeep Jain A, Dsouza DL, Ali R.   +10 more
europepmc   +2 more sources

Precise multimodal optical control of neural ensemble activity. [PDF]

, 2018
Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a multiphoton holographic approach to activate or suppress the activity of ensembles of ...
Adesnik, Hillel, Brohawn, Stephen G, Chesnov, Kirill, Lyall, Evan H, Mardinly, Alan R, Oldenburg, Ian Antón, Pégard, Nicolas C, Sridharan, Savitha, Waller, Laura   +8 more
core   +1 more source

Highly Inflamed Non-Calcified Coronary Plaques Sealed with Stents in Patients with Zero Calcium Score – a Case Series and Review of the Literature

Journal of Cardiovascular Emergencies, 2023
The modern management of coronary artery disease (CAD) uses coronary computed tomography angiography (CCTA) to enhance plaque evaluation and cardiovascular risk assessment.
Mátyás Botond-Barna, Gerculy Renáta, Rat Nóra, Blîndu Emanuel, Stănescu Alexandra Gorea, Roșca Aurelian, Buicu Corneliu-Florin, Benedek Imre, Benedek Theodora   +8 more
doaj   +1 more source

Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience. [PDF]

, 2019
Identifying low-dimensional features that describe large-scale neural recordings is a major challenge in neuroscience. Repeated temporal patterns (sequences) are thought to be a salient feature of neural dynamics, but are not succinctly captured by ...
Bahle, Andrew H, Denisenko, Natalia I, Fee, Michale S, Goldman, Mark S, Gu, Shijie, Mackevicius, Emily L, Williams, Alex H   +6 more
core   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Calcium score as a screening method for cardiovascular disease diagnosis

Российский кардиологический журнал, 2019
Coronary artery calcification (CAC) is characteristic of coronary atherosclerosis, which is often detected by chest computed tomography. The standardized method for assessing CAC is the calcium score (CS) using the Agatston scoring system.
K. N. Zhuravlev, E. Yu. Vasilieva, V. E. Sinitsyn, A. V. Spector   +3 more
doaj   +1 more source