Results 61 to 70 of about 101,823 (276)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
What Is the Prognostic Value of a Zero Calcium Score?
Journal of the American College of Cardiology, 2010 Despite remarkable advances in knowledge and technology, heart disease remains the leading cause of death in the U.S. Thus, the search continues for more effective ways to diagnose heart disease early, and hopefully prevent more cardiac deaths. More than 30 years ago, Diamond and Forrester ([1][1])
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. [PDF]
, 2015 BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events.
Blaha, Michael J +7 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Human Nutrition & Metabolism, 2023 Adequate nutrition during infancy and early childhood is essential to ensure children's growth, health, and development to their full potential. Geographical area may influence dietary intake and, hence, the population's nutritional status.
J.D. Mrema, C.N. Nyaruhucha, A.W. Mwanri
doaj +1 more source
CA1-projecting subiculum neurons facilitate object-place learning. [PDF]
, 2019 Recent anatomical evidence suggests a functionally significant back-projection pathway from the subiculum to the CA1. Here we show that the afferent circuitry of CA1-projecting subicular neurons is biased by inputs from CA1 inhibitory neurons and the ...
Chen, Lujia +12 more
core +1 more source
Sparsest factor analysis for clustering variables: a matrix decomposition approach [PDF]
, 2017 We propose a new procedure for sparse factor analysis (FA) such that each variable loads only one common factor. Thus, the loading matrix has a single nonzero element in each row and zeros elsewhere.
A Stegeman +33 more
core +1 more source
Spatially Weighted Calcium Score Beyond Power of Zero [PDF]
Circulation: Cardiovascular Imaging, 2021 Marcio Sommer Bittencourt, Khurram Nasir
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source