Results 61 to 70 of about 192,785 (264)

The decay rates of solutions to a chemotaxis-shallow water system

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2021
In this paper, we consider the large time behavior of solution for the chemotaxis-shallow water system in $\mathbb{R}^2$. The lower bound for time decay rates of the bacterial density and the chemoattractant concentration are proved by the method of ...
Yanqiu Huang, Qiang Tao
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the Empirical (Ir)Relevance of the Zero Lower Bound Constraint [PDF]

open access: yesNBER Macroeconomics Annual, 2019
The magnitude of the global financial crisis of 2007–8 and the recession that it triggered ledmany central banks to lower their policy rates down to values near zero, their theoretical lower bound.1 In the United States, the target for the federal funds rate remained at zero for 7 years, from January 2009 through December 2015.
Debortoli, Davide   +2 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Public Investment, Time to Build, and the Zero Lower Bound [PDF]

open access: yesSSRN Electronic Journal, 2014
Abstract We study the effectiveness of public investment in stimulating an economy stuck in a liquidity trap. We do so in the context of a tractable new-Keynesian economy in which a fraction of government spending increases the stock of public capital subject to a time-to-build constraint.
Bouakez, Hafedh   +2 more
openaire   +5 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Transport coefficients in non-quasiparticle systems

open access: yesEPJ Web of Conferences, 2011
Transport coefficients, in particular the shear viscosity to entropy density ratio are studied in systems where the small-width quasiparticle assumption is not valid.
Jakovác A.
doaj   +1 more source

Projection to Mixture Families and Rate-Distortion Bounds with Power Distortion Measures

open access: yesEntropy, 2017
The explicit form of the rate-distortion function has rarely been obtained, except for few cases where the Shannon lower bound coincides with the rate-distortion function for the entire range of the positive rate. From an information geometrical point of
Kazuho Watanabe
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Oil, Equities, and the Zero Lower Bound [PDF]

open access: yesFinance and Economics Discussion Series, 2018
From late 2008 to 2017, oil and equity returns were more positively correlated than in other periods. In addition, we show that both oil and equity returns became more responsive to macroeconomic news. We provide empirical evidence and theoretical justification that these changes resulted from nominal interest rates being constrained by the zero lower ...
Deepa Datta   +3 more
openaire   +1 more source

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