Results 41 to 50 of about 106,979 (247)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

An Adaptive Information Security System for 5G-Enabled Smart Grid Based on Artificial Neural Network and Case-Based Learning Algorithms

Frontiers in Computational Neuroscience, 2022
With the deployment of 5G Internet of Things (IoT) in the power system, the efficiency of smart grid is improved by increasing two-way interactions in different layers in smart grid.
Chengzhi Jiang, Chengzhi Jiang, Hao Xu, Hao Xu, Chuanfeng Huang, Qiwei Huang   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Toward zero trust in 5G Industrial Internet collaboration systems

Digital Communications and Networks
With the introduction of 5G, users and devices can access the industrial network from anywhere in the world. Therefore, traditional perimeter-based security technologies for industrial networks can no longer work well.
Han Zhang, Ziyan Zhang, Liquan Chen
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The significance of artificial intelligence in zero trust technologies: a comprehensive review

Journal of Electrical Systems and Information Technology
In the era of cloud computing, cybersecurity has assumed paramount importance. As organizations transition to cloud-based solutions, cyberattackers increasingly target cloud services as a lucrative avenue for unauthorized access to sensitive information.
Deepa Ajish
doaj   +1 more source

Using the Zero Trust Five-Step Implementation Process with Smart Environments: State-of-the-Art Review and Future Directions

Future Internet
There is a growing pressure on industry to secure environments and demonstrate their commitment in taking right steps to secure their products. This is because of the growing number of security compromises in the IT industry, Operational Technology ...
Shruti Kulkarni, Alexios Mylonas, Stilianos Vidalis   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Securing the Metaverse: A Blockchain-Enabled Zero-Trust Architecture for Virtual Environments

IEEE Access
In order to improve cybersecurity in newly developed network infrastructures, this research investigates the integration of blockchain technology with zero-trust security concepts. The zero-trust paradigm ensures continuous authentication across entities,
Ikram Ud Din, Kamran Habib Khan, Ahmad Almogren, Mahdi Zareei, Jesus Arturo Perez Diaz   +4 more
doaj   +1 more source