Results 91 to 100 of about 136,294 (309)

N, S Co‐Doped Carbon Quantum Dots‐Riboflavin Composite Photosensitizers for Enhanced Iontophoresis‐Assisted Corneal Cross‐Linking

Advanced Science, EarlyView.
This study explores the use of N, S co‐doped carbon quantum dots (NS‐CQDs) as carriers for riboflavin, creating NS‐CQDs‐RF composite photosensitizers. These composites improve riboflavin absorption, enhance ROS generation efficiency, and preserve corneal epithelium integrity.
Tinghong Xu, Yong Liu, Wenjing Zhang, Qiuruo Jiang, Yi Jin, Liangzheng Lin, Lumeng Wang, Zhanhao Gu, Mimi Lin, Shihao Chen   +9 more
wiley   +1 more source

Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death

[EN] Introduction Cervical cancer, predominantly caused by high-risk human papillomavirus (HPV), remains a major global health challenge. HPV16 is the most prevalent type, and its oncoprotein E7 promotes epithelial-mesenchymal transition (EMT), a ...
Yang, Jiani, Li, Wenshu, Tan, Xiaochun, Wan, Kairong, Jing, Xishang, Li, Yanheng, Zhang, Lifang, Feng, Sicong, Xie, Zhenyun   +8 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Reducing Mortality in AIS Patients After EVT: Challenges and Prospective Strategies [Letter]

Clinical Interventions in Aging
Yuqiu Lu,1 Lingtian Weng,2 Tianmei Zhou3 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People’s Republic of China; 2The First School of Clinical Medicine, Zhejiang Chinese Medical ...
Lu Y, Weng L, Zhou T
doaj  

A novel bispecific affitoxin simultaneously targeting E7 of HPV16/18 types: superior anti-tumor activity and EMT reversal in HPV-driven cervical cancer therapy

[EN] BackgroundSustained infection with high-risk HPV of the 16 and 18 types is accounted for nearly 75% of cervical cancer (CC), but now there is an absence of agents aimed at eradicating HPV infections.
Li, Wenshu, Wan, Kairong, Jing, Xishang, Yu, Lijun, Li, Yanheng, Zhang, Lifang, Wu, Junze, Xie, Zhenyun, Feng, Sicong   +8 more
core   +1 more source

Fig. 1 in Crickets (Orthoptera: Grylloidea) from Zhejiang Province, China

, 2019
Fig. 1. Map of Zhejiang and adjacent provinces of China with location of twelve mountainsPublished as part of Xu, F. & Liu, H.-Y., 2019, Crickets (Orthoptera: Grylloidea) from Zhejiang Province, China, pp. 25-36 in Far Eastern Entomologist 394 on page 26,
Liu, H.-Y., Xu, F.
core   +1 more source

Supplemental Material: The long-lived transcrustal magmatic systems of Southeast China in response to paleo-Pacific plate subduction, recorded by the Cretaceous volcanic sequences in southeastern Zhejiang Province

, 2022
Table S1: Zircon LA-ICP-MS U-Pb dating results of the volcanic rocks in SE Zhejiang Province. Table S2: Trace elements (ppm) in zircon from the volcanic rocks in SE Zhejiang Province acquired by LA-ICP-MS.
Liang Liu (12914699), Jie-Hua Yang (12914702), et al. (281964)   +2 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Studies on the population number of waterfowls in Zhejing Province

浙江大学学报. 农业与生命科学版, 2001
The population number, density and diversity of waterfowls in Zhejiang Province were surveyed from April 1997 to July 1999, with the systematic sampling, line transect and point count methods.7 orders, 13 families and 97 species of waterfowl with 53.6 ...
LIU An-xing, CHEN Zheng-hai, DING Ping, SUN Meng-jun, DU Qun   +4 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source