Structure–Activity Relationship of the Dimeric and Oligomeric Forms of a Cytotoxic Biotherapeutic Based on Diphtheria Toxin [PDF]
Biomolecules, 2022 Protein aggregation is a well-recognized problem in industrial preparation, including biotherapeutics. These low-energy states constantly compete with a native-like conformation, which is more pronounced in the case of macromolecules of low stability in ...
Marcin Mielecki +6 more
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Effect of Iron Ion on Corrosion Behavior of Inconel 625 in High-Temperature Water. [PDF]
Scanning, 2020 The corrosion behavior of an ultralow iron nickel‐based alloy Inconel 625 under high‐temperature water has been evaluated. The results show that surface oxidation and pitting were the principal corrosion mechanisms of Inconel 625 during the initial immersion period.
Zhou H +8 more
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Understanding the selectivity of nonsteroidal anti-inflammatory drugs for cyclooxygenases using quantum crystallography and electrostatic interaction energy [PDF]
IUCrJQuantum crystallography methods have been employed to investigate complex formation between nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) enzymes, with particular focus on the COX-1 and COX-2 isoforms.
S. Pawlędzio +4 more
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MicroED: Unveiling the Structural Chemistry of Plant Biomineralisation [PDF]
MoleculesPlants are able to produce various types of crystals through metabolic processes, serving functions ranging from herbivore deterrence to photosynthetic efficiency.
Damian Trzybiński +8 more
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Potent Biological Activity of Fluorinated Derivatives of 2-Deoxy-d-Glucose in a Glioblastoma Model [PDF]
BiomedicinesBackground: One defining feature of various aggressive cancers, including glioblastoma multiforme (GBM), is glycolysis upregulation, making its inhibition a promising therapeutic approach.
Maja Sołtyka-Krajewska +12 more
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Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection. [PDF]
PLoS ONE, 2017 The latent reservoir is a major barrier to HIV eradication. Reservoir size is emerging as an important biomarker to assess the likelihood of HIV remission in the absence of antiretroviral therapy (ART) and may be reduced by earlier initiation of ART that
Kaitlin Rainwater-Lovett +11 more
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Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis [PDF]
Nature Communications, 2018 The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators.
Jeffrey S. Mugridge +4 more
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Characterization of cognitive decline in long-duration type 1 diabetes by cognitive, neuroimaging, and pathological examinations [PDF]
JCI InsightBACKGROUND We aimed to characterize factors associated with the under-studied complication of cognitive decline in aging people with long-duration type 1 diabetes (T1D).METHODS Joslin “Medalists” (n = 222; T1D ≥ 50 years) underwent cognitive testing ...
Hetal S. Shah +21 more
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Zmiany w produkcji, handlu zagranicznym i zużyciu krajowym ziemniaków w Polsce w latach 2001-2019
Zeszyty Naukowe Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie. Problemy Rolnictwa Światowego, 2021 Przedmiotem analizy była produkcja ziemniaków, zużycie krajowe i obroty handlu zagranicznego (eksport i import) w Polsce w latach 2001-2019. W oparciu o wyniki analiz określono średniookresową projekcję (na 2025 r.) obejmującą produkcję, kierunki ...
Stanisław Stańko, Aneta Mikuła
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Ocena plonowania i jakości bulw po aplikacji dolistnej krzemu i mikroelementów
Agronomy Science, 2021 W latach 2017–2019 przeprowadzono na glebie lekkiej badania polowe nad określeniem wpływu dolistnego dokarmiania roślin ziemniaka nawozem krzemowym (Krzemian) na wielkość plonu i wybrane cechy jakości bulw ziemniaka.
Cezary Trawczyński
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