Results 41 to 50 of about 182,639 (263)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Synthesis and Fluorescence Properties of Asymmetrical Salamo-Type Tetranuclear Zinc(II) Complex

Crystals, 2018
A new tetranuclear zinc(II) complex with an asymmetrical Salamo-type chelating ligand, H3L (5-methoxy-6′-hydroxy-2,2′-[ethylenedioxybis(nitrilomethylidyne)]diphenol), was synthesized and characterized using FT-IR, elemental analyses, X-ray single crystal
Yun-Dong Peng, Xiao-Yan Li, Quan-Peng Kang, Gao-Xian An, Yang Zhang, Wen-Kui Dong   +5 more
doaj   +1 more source

Antibacterial and antifungal activity of zinc(II) complexes with some 2-methylbenzimidazole derivatives [PDF]

Acta Periodica Technologica, 2005
Zinc(II) chloride reacts with 2-methylbenzimidazole derivatives to give complexes of the formula ZnL2Cl2-nH2O, where L=2-methylbenzimidazole l-benzyl-2-methylbenzimida-zole and l-(4-methylbenzyl)-2-methylbenzimidazole n=0, 0.5 or 1.
Podunavac-Kuzmanović Sanja O., Cvetković Dragoljub D., Ćetković Gordana S.   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Study the optimal Conditions for the Determination of Zinc (II) in Aqueous Solutions Using Organic Reagent 4-Hydroxy - 3 -[[hydroxy phenyl) methylene] amino] benzene sulphonic acid II by Spectrophotometric method

Syrian Journal for Science and Innovation
Spectrophotometric methods using organic reagents are among the most used methods because of their rapid, simplicity, low cost, and wide range of applications.
Mohammad Maarouf, Ammar Kheder Ismaiel
doaj   +1 more source

Substituted Halo Complexes of Zinc (II)

, 1969
Tetrahalo zinc(II) complexes were reacted with several substituted pyridines and quinoline in ethanolic medium. Seven, more usual tetra-coordinated and two, less common penta-coordinated mixed ligand anionic complexes were characterised by analyses, conductance and infrared spectra.
S. Guru, D. V. Ramana Rao
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source