Results 51 to 60 of about 12,533 (181)

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

Metabolic Syndrome Screening in Seriously Mentally Ill Patients: A Quality Improvement Project [PDF]

, 2016
A Project Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE in Nursing ScienceSeriously mentally ill patients who are taking second-generation antipsychotics have a high risk of metabolic complications ...
Moreno, Annabel
core  

Response to antipsychotic drugs in treatment-resistant schizophrenia : Conclusions based on systematic review [PDF]

, 2016
Peer ...
Corripio, I., Isohanni, M., Jaaskelainen, E., Koponen, Hannu, M-RESIST Grp, Miettunen, J., Moilanen, J., Molins, C., Roldan, A., Seppala, A., Seppala, J.   +10 more
core   +2 more sources

Altered Brain Tissue Volumes With Valproate Treatment for Schizophrenia

Journal of the Royal Society of New Zealand, Volume 56, Issue 2, April 2026.
Schizophrenia is a debilitating psychiatric condition that affects ≈0.5% of the global population. Some people with schizophrenia do not respond to first‐line antipsychotics and are prescribed clozapine; this is termed treatment‐resistant schizophrenia (TRS).
Thomas Cawood, Olivia K. Harrison, Meghan McIlwain, Robert R. Kydd, Bruce R. Russell   +4 more
wiley   +1 more source

ZIPRASIDONE: A NEW ATYPICAL ANTIPSYCHOTIC AGENT

Psychiatry and Clinical Psychopharmacology, 2021
Ziprasidone is a benzisothiazol piperazine derivative with a higher therapeutic efficacy and a favourable tolerability profile in the treatment of schizophrenia. Ziprasidone has a high 5-HT2 to D2 receptor binding ratio and also binds with high affinity
Artuner Deveci, Ayşen Esen Danacı
doaj  

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study

Molecules, 2020
Schizophrenia is a severe, chronic mental illness characterized by delusions, hallucinations, negative symptoms, and cognitive dysfunction. Recently, several studies have demonstrated that the pathogenesis of schizophrenia involves mitochondrial ...
Kazuki Terada, Ayumi Murata, Erina Toki, Shotaro Goto, Hirofumi Yamakawa, Shuichi Setoguchi, Daisuke Watase, Mitsuhisa Koga, Jiro Takata, Kazuhisa Matsunaga, Yoshiharu Karube   +10 more
doaj   +1 more source

Establishing gold standard approaches to rapid tranquillisation: a review and discussion of the evidence on the safety and efficacy of medications currently used [PDF]

, 2008
Background: Rapid tranquillisation is used when control of agitation, aggression or excitement is required. Throughout the UK there is no consensus over the choice of drugs to be used as first line treatment.
Branford, David, Chandler-Oatts, Jacqueline, Johnston, Susan, Nelstrop, Louise, Pereira, Stephen M., Pratt, J. Peter   +5 more
core   +1 more source

QTc and psychopharmacs: are there any differences between monotherapy and polytherapy [PDF]

, 2007
Background Some psychotropic drugs are connected with prolongation of QT interval, increased risk of cardiac arrhythmias and greater incidence of sudden death, especially when used in combination.
Jadranka Čulav Sumić, Vesna Barić, Petar Bilić, Miroslav Herceg, Mirna Sisek-Šprem, Vlado Jukić, SMJM Straus, SMJM Straus, DM Gardner, S Hennessy, M Fayek, WVR Vieweg, AH Glassman, BJ Drew, Committee for Medicinal Products for Human Use, J Cheng, TV Pham, M-D Drici, H Ito, C Van Mieghem, A Llerena, P O'Brien, AJ Moss, RS Kass, AJ Moss, cE Clancy, SG Priori, DM Roden, P Yang, JS Mitcheson, M Sala, WHO, SM Al-Khatib, CAW Rijcken, W Haverkamp, SU Shah   +35 more
core   +2 more sources

Functional, Contextual, and Interventional Drivers of Formal Coercion in Acute Mental Health Units: A Feature Analysis

International Journal of Mental Health Nursing, Volume 35, Issue 1, February 2026.
ABSTRACT Minimising formal coercion, such as seclusion, physical restraint, and forced medication, remains a global priority in acute mental health units. However, key drivers beyond individual‐level features are poorly understood. This exploratory analysis was intended to identify the top functional, contextual, and interventional features linked to ...
Esario IV Daguman, Jacqui Yoxall, Richard Lakeman, Marie Hutchinson   +3 more
wiley   +1 more source