Results 71 to 80 of about 14,464 (157)

Ziv-aflibercept: a novel option for the treatment of polypoidal choroidal vasculopathy. [PDF]

BMJ Case Rep, 2015
Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy usually treated using photodynamic therapy (PDT) and antivascular endothelial growth factor agents. However, these cases may sometimes be refractory to both PDT and ranibizumab or bevacizumab, and may have persistent intra-retinal fluid. Recently, studies have reported that aflibercept
Videkar C, Kapoor A, Chhablani J, Narayanan R.   +3 more
europepmc   +4 more sources

Comparison between ziv-aflibercept and ranibizumab for treatment of diabetic macular edema

Journal of the Egyptian Ophthalmological Society
Aim To evaluate safety and efficacy of ziv-aflibercept in comparison to ranibizumab for the treatment of diabetic macular edema (DME). Patients and methods A total of 84 patients (84 eyes) with DME and central macular thickness (CMT) greater than 350 μ ...
Abdalah S. Nasr, Mahmoud A. Ali, Sherif A. Dabbor, Ahmed F. Gabr   +3 more
doaj   +1 more source

Antiangiogenic and Antitumor Activities of Aflibercept, a Soluble VEGF Receptor-1 and -2, in a Mouse Model of Hepatocellular Carcinoma

Neoplasia: An International Journal for Oncology Research, 2016
BACKGROUND & AIM: Aflibercept known as ziv-aflibercept in the United States is a soluble decoy receptor of both vascular endothelial growth factor (VEGF) receptor-1 and -2 known to inhibit the binding of VEGF and placental growth factor (PlGF) to VEGF ...
Takuji Torimura, Hideki Iwamoto, Toru Nakamura, Mitsuhiko Abe, Yu Ikezono, Fumitaka Wada, Takahiko Sakaue, Hiroshi Masuda, Osamu Hashimoto, Hironori Koga, Takato Ueno, Hirohisa Yano   +11 more
doaj   +1 more source

Delivery System and Nanozyme: Nanotechnology‐Based Natural Sources Promise New Approaches in Colorectal Cancer Management

Micro &Nano Letters, Volume 21, Issue 1, January/December 2026.
The paper examines how nanotechnology‐based drug delivery systems using biocompatible nanoparticles function to improve drug pharmacokinetics and deliver medication to tumours while minimising adverse effects. ABSTRACT The worldwide prevalence of colorectal cancer (CRC) makes it a leading cause of death among malignancies.
Ghazala Muteeb, Rawan S. Elsharkawy, Ayda H. El‐Gouhari, Ghannimah Yousef Alghuwainem, Mohammad Aatif, Doaa S. R. Khafaga   +5 more
wiley   +1 more source

Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Uveal melanoma (UM) is the prevailing malignant tumor that develops within the eye in adults, and it has a bleak outlook because of the few treatment choices available and the high likelihood of returning after treatment. Currently, surgical intervention, radiation therapy, and a combination of both modalities are available ...
Alireza Azani, Vahid Ghassemifar, Zahra Mehrdad, Maryam Saberivand, Anahid Bagheripour, Safa Tahmasebi, Hossein Gharedaghi, Malihe Sharafi, Hassan Foroozand, Mohammad Saeed Soleimani Meigoli, Saba Pourali, Arash Salmaninejad, Faeze Ahmadi Beni, Qumars Behfar   +13 more
wiley   +1 more source

Autofluorescence indexes as biomarkers for antiangiogenic loading dose outcome in diabetic macular edema

Therapeutic Advances in Ophthalmology, 2020
Purpose: To evaluate the combination of fundus autofluorescence results with several clinical and structural variables into mathematical indexes to enhance their ability to predict visual and anatomical changes after the antivascular endothelial growth ...
Sergio E. Hernández Da Mota, Francisco Béjar Cornejo, Marcela Esquivel Velázquez, Virgilio Lima Gómez, Gerardo González Saldívar, Ernesto Rodríguez Ayala, Raul Vélez-Montoya   +6 more
doaj   +1 more source

Angiogenesis Inhibitors in Small Cell Lung Cancer

Frontiers in Oncology, 2021
Inhibition of angiogenesis has been demonstrated to be an efficacious strategy in treating several tumors. Vascular endothelial growth factor (VEGF) is the most important protein with proangiogenic functions and it is overexpressed in small cell lung ...
Agnese Montanino, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Gerardo Botti, Maria C. Piccirillo, Priscilla Cascetta, Giacomo Pascarella, Carmine La Manna, Nicola Normanno, Alessandro Morabito   +14 more
doaj   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 591-605, October 2024.
Fisetin has been shown to exhibit significant impact on colorectal cancer (CRC) in animal models by targeting various cellular and molecular mechanisms. It inhibits the phosphorylation of Y‐box binding protein 1 and ribosomal S6 kinase and promotes the phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK1/2), thereby disrupting the repair ...
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
wiley   +1 more source

Enhancing cancer immunotherapy and antiangiogenic therapy by regulating gut microbes: Opportunities and challenges

MedComm – Oncology, Volume 3, Issue 3, September 2024.
Immune checkpoint therapy is the main means of cancer treatment. However, most patients develop strong resistance to it. Another cancer treatment is antiangiogenic therapy. It enhances tumor immune response. Gut microbes enhance the efficacy of immunotherapy. We hope that the three of them will be able to treat cancer together.
Jie Xu, Yaomei Tian, Die Hu, Xi Yan, Li Yang   +4 more
wiley   +1 more source