Results 71 to 80 of about 19,002 (159)
Natural products targeting tumour angiogenesis
British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 591-605, October 2024.Fisetin has been shown to exhibit significant impact on colorectal cancer (CRC) in animal models by targeting various cellular and molecular mechanisms. It inhibits the phosphorylation of Y‐box binding protein 1 and ribosomal S6 kinase and promotes the phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK1/2), thereby disrupting the repair ...
Mohammad Yasin Zamanian +9 more
wiley +1 more source
Therapeutic Advances in Ophthalmology, 2020 Purpose: To evaluate the combination of fundus autofluorescence results with several clinical and structural variables into mathematical indexes to enhance their ability to predict visual and anatomical changes after the antivascular endothelial growth ...
Sergio E. Hernández Da Mota +6 more
doaj +1 more source
Angiogenesis Inhibitors in Small Cell Lung Cancer
Frontiers in Oncology, 2021 Inhibition of angiogenesis has been demonstrated to be an efficacious strategy in treating several tumors. Vascular endothelial growth factor (VEGF) is the most important protein with proangiogenic functions and it is overexpressed in small cell lung ...
Agnese Montanino +14 more
doaj +1 more source
MedComm – Oncology, Volume 3, Issue 3, September 2024.Immune checkpoint therapy is the main means of cancer treatment. However, most patients develop strong resistance to it. Another cancer treatment is antiangiogenic therapy. It enhances tumor immune response. Gut microbes enhance the efficacy of immunotherapy. We hope that the three of them will be able to treat cancer together.
Jie Xu +4 more
wiley +1 more source
Technology in Cancer Research & Treatment, 2020 Background: Association of drugs acting against different antiangiogenic mechanisms may increase therapeutic effect and reduce resistance. Noninvasive monitoring of changes in the antiangiogenic response of individual tumors could guide selection and ...
Michele Lamuraglia MD, PhD +8 more
doaj +1 more source
Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy
Journal of Hematology & Oncology, 2012 The diverse pathways and molecules involved in angiogenesis, the formation of new blood vessels, have been targeted for the treatment of colorectal and other cancers.
Sun Weijing
doaj +1 more source
Progression of Ziv-aflibercept on metastatic colorectal cancer [PDF]
, 2015 针对特异性分子靶点的靶向药物治疗已成为转移性结直肠癌(M CrC)治疗的新方向。2012年zIV-阿柏西普被美国食品和药物管理局批准用于M CrC患者,zIV-阿柏西普是一种作用于血管生成信号通路的重组融合蛋白,通过与血管内皮生长因子(VEgf)受体结合,从而阻断肿瘤的生长和转移。一项Ⅲ期临床研究结果显示zIV-阿柏西普能显著延长M CrC患者的生存期。本文结合国内外最新研究报道,对zIV-阿柏西普治疗M CrC的研究进展作一综述。Targeted drug therapy for specific ...
宋敏
core
Southwest Oncology Group S0802: A Randomized, Phase II Trial of Weekly Topotecan With and Without Ziv-Aflibercept in Patients With Platinum-Treated Small-Cell Lung Cancer [PDF]
, 2014 PURPOSE: Development of new therapies for previously treated small-cell lung cancer (SCLC) is a major unmet need. Here, we describe a randomized, phase II trial of weekly topotecan with or without ziv-aflibercept (VEGF-trap) in this clinical setting ...
Jahanzeb, Mohammad +9 more
core +1 more source
Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema: Exploratory Retrospective Analysis [PDF]
, 2021 Aim: To evaluate the efficacy of switching from bevacizumab to ranibizumab or aflibercept in eyes with diabetic macular edema (DME) unresponsive to bevacizumab.
Meireles, Angelina +11 more
core +1 more source