Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Generalized projections in Zn [PDF]
AKCE International Journal of Graphs and Combinatorics, 2019 We consider the ring $\mathbb Z_n$ (integers modulo $n$) with the partial order `$\leq$' given by `$a \leq b$ if either $a=b$ or $a\equiv ab~(mod~n)$'. In this paper, we obtain necessary and sufficient conditions for the poset ($\mathbb Z_n,~\leq$) to be a lattice.
A.S. Khairnar, B.N. Waphare
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Insights on Zn deficiency and Zn excess effects on the Root Apical Meristem in Arabidopsis
, 2022 Zinc, an essential cofactor to many enzymes, is an important micronutrient in plants. Crop culture on Zn deficient soils, which are widespread worldwide, is limiting productivity and quality and is considered as a concern for human nutrition. In contrast,
Persson, Daniel P. +6 more
core +1 more source
Evaluation of Zn in Acid Mine Drainage in the Ohitachi Mining Area, Akita Prefecture, Japan
Journal of MMIJ, 2018 Environmental impact assessment was conducted at the Ohitachi Mine (Cu-Zn-Pb) located in Odate, Akita Prefecture, Japan. Zn concentration in river water exceeded the environmental standard (30 µg/L) even in the downstream of the Mine.
Kengo SAWAYAMA, Noriyoshi TSUCHIYA
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Manganese and zinc in acidic agricultural soils from Central Spain: Distribution and phytoavailability prediction with chemical extraction tests [PDF]
, 2009 The extractability and distribution of manganese (Mn) and zinc (Zn) were evaluated in acidic agricultural soils from Central Spain. Both single (0.1 M hydrochloride [HCl] and 0.05 M ethylenediaminetetraacetate [EDTA]) and sequential extraction procedures
Rico Selas, M.Isabel +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Simple manufacturing and metal type-dependent properties of M3(OH)2V2O7•nH2O (M; Co, Ni, Cu, Zn) nanostructures [PDF]
Nanochemistry Research, 2020 M3(OH)2V2O7·nH2O ( M : Co, Ni, Cu, Zn) nanostructures were synthesized by a simple and economic chemical precipitation route. For Co and Ni compounds, very small (~9 nm), irregularly shaped and poor crystalline nanoparticles occurred, probably due to ...
Berna Bülbül +3 more
doaj +1 more source
Zn-3Ag biodegradation by simulated body fluid.
, 2019 Zn concentration measured by atom absorption spectroscopy (AAS) after immersion of Zn-3Ag alloy samples in simulated body fluid (SBF) at the time of fluid change for 85 days were shown.
Nadia Kress (6169532) +15 more
core +1 more source