Results 101 to 110 of about 5,114,489 (264)

Characteristics and Outcomes of Second Primary Multiple Myeloma in Adult Cancer Survivors: A Population‐Based Cohort Study

Cancer Medicine, Volume 14, Issue 22, November 2025.
By leveraging SEER registry data (2000–2021) with rigorous competing risk analysis, we found that second primary multiple myeloma, considered as a vital prognostic factor, exhibited distinct characteristics and survival outcomes compared to first primary multiple myeloma in US adults, which were associated with prior primary malignancy types and their ...
Nannan Li, Jiangping Zeng, Zhixiang Jia, Jinyuan Lu, Yuting Ma, Guangming Wang, Aibin Liang, Wenjun Zhang   +7 more
wiley   +1 more source

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis [PDF]

, 2012
Recent data from the AZURE, ABCSG-12, and ZO-FAST clinical trials have challenged our understanding of the potential anticancer activity of zoledronic acid (ZOL). Although the results of these studies may appear to be conflicting on the surface, a deeper
Arrington, Avcu, Baum, Bilezikjian, Binkley, Bismar, Black, Bourdeau, Brown, Bundred, Burger, Burger, Centrella, Chapman, Cheleuitte, Chiu, Clowes, Coleman, Coscia, Coxon, Croucher, de Boer, Del Mastro, Dixon, Duivenvoorden, Edlund, Edlund, Esparza-Lopez, Folkerd, Gasser, Gasser, Geisler, Giraudo, Gnant, Gnant, Gnant, Gnant, Gordon, Guo, Hackshaw, Hamilton, Hampl, Hershman, Hershman, Hines, Hiraga, Hofbauer, Hornby, Ibrahim, Jimenez-Gordo, Juarez, Kaplan, Kaplan, Kardassis, Khosla, Kirkbride, Labrinidis, Le Goff, Lee, Lewis, Lindberg, Little, Little, Meads, Melani, Monkkonen, Muller, Nicks, Ogata, Ottewell, Ottewell, Ottewell, Pataki, Perrien, Perrien, Peyruchaud, Pfeilschifter, Podworny, Rachner, Rannevik, Roelofs, Rogers, Rosen, Rosen, Saika, Sasser, Sasser, Shiozawa, Shipman, Sims, Sirola, Skerjanec, Sowers, Studebaker, Sun, Tang, Thompson, Thurlimann, Uncu, van de Velde, Weiss, Wels, Welt, Wiater, Winter   +104 more
core   +1 more source

Bilateral Orocutaneous Fistulas and Mandibular Osteonecrosis

International Journal of Dermatology, EarlyView.
Krisztian Nemeth, Mollye Goldberg, Zachary Fridirici   +2 more
wiley   +1 more source

Unexpected Long‐Term Disease Control in Lung Cancer With Sacral Metastases After Conventional Radiotherapy and Chemotherapy Despite Discontinuation of Maintenance Therapy: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Novel treatments, including stereotactic body radiotherapy (SBRT), targeted therapies, and immune checkpoint inhibitors (ICIs), have improved the prognosis and outcomes of patients with metastatic lung cancer. However, not all patients are eligible for these treatments; furthermore, these novel therapies are not readily available in developing
Reyhaneh Bayani, Mahdi Khakpour, Behnaz Jahanbin, Nima Mousavi Darzikolaee   +3 more
wiley   +1 more source

Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial

Journal of Bone Oncology, 2019
Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven. Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with ...
Shenglong Li, Peng Chen, Qiankun Yang
doaj   +1 more source

Future directions for the management of pain in osteoarthritis. [PDF]

, 2014
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA
Aigner T, Anasuya Kuttapitiya, Balanescu AR, Bannuru RR, Chou R, da Costa BR, Danielsson L, Fanelli A, Fransen M, Haviv B, Huskisson EC, Lim YZ, Mankin HJ, McAlindon TE, Merlotti D, Nguyen US, Nidhi Sofat, Pelletier JP, Sagar DR, Sellers RS, Sofat N, Tannenbaum H, Wajed J, Wakitani S   +23 more
core   +1 more source

Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid

Scientific Reports, 2019
Bisphosphonates are frequently used for the antiresorptive treatment in bone metastasis diseases or for osteoporosis. A side effect of this therapy is osteonecrosis of the jaw.
D. Steller, Nele Herbst, R. Pries, D. Juhl, S. Hakim   +4 more
semanticscholar   +1 more source

Cordycepin Targets HRD1 to Promote Cancer Cell PD‐L1 Ubiquitin–Proteasome Degradation and Increase Antitumor Immunity

MedComm, Volume 6, Issue 11, November 2025.
Using an activity‐based tracking approach, our study revealed that the component in Cordyceps militaris extract (CME) that reduces PD‐L1 activity is cordycepin, which demonstrates potential as an immune checkpoint inhibitor for colorectal cancer. Cordycepin targets HRD1, leading to PD‐L1 protein degradation via the ubiquitin–proteasome pathway, which ...
Xiangxin Geng, Minchen Cai, Hongmei Hu, Mengting Xu, Qing Zhang, Hanchen Xu, Dianping Yu, Hongwei Zhang, Hanchi Xu, Linyang Li, Mengmeng Guo, Shize Xie, Qun Wang, Weidong Zhang, Sanhong Liu   +14 more
wiley   +1 more source

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study [PDF]

, 2013
Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients ...
Alcaraz, A., Anido, Urbano, Bellmunt, Joaquim, Calderero, Verónica, Carles, Joan, Comet-Batlle, Josep, Constela, Manuel, Contreras, José Antonio Viedma, De La Piedra, Concepción, Del Alba, Aránzazu González, Delgado, Diego Hernán, Esteban, Emilio, Fernández, Jesús María, García-Escudero, Antonio, González Enguita, Carmen, González-Gragera, B., Gómez Caamaño, Antonio, Gómez-Veiga, Francisco J., Lara, Pedro Carlos, Lassa, A., Mahillo, Ignacio, Martín-Fernández, Marta, Martínez Javaloyas, J. M., Mañas, Ana, Meseguer, Cristina, Moróte, Juan Moróte, Murias, Adolfo, Méndez, Míriam J., Quicios, C., Reynés, Gaspar, Ribal, María José, Rodríguez, Begoña I., Rubio, Gustavo, Samper, Pilar María, San José, L. A., Segarra, José, Solsona, Eduardo, Sánchez, Ernesto Sánchez, Tabernero, Ángel J., Unda, Miguel, Virizuela, Juan Antonio, Vázquez, Fernando Javier, Álvarez-Ossorio, Jose Luis   +42 more
core   +2 more sources

The Impact of Polyploid Giant Cancer Cells: The Root of Stress Resilience

Cancer Science, Volume 116, Issue 11, Page 2949-2958, November 2025.
Among the diverse characteristics of polyploid giant cancer cells (PGCCs) observed in various contexts, stress resilience is one of their key features, enabling survival and adaptation under harsh conditions. This review discusses the unique stress tolerance mechanisms of PGCCs and their implications for cancer progression, therapy resistance, and ...
Yuta Ogawa, Lydia Fisher, Tomonori Matsumoto   +2 more
wiley   +1 more source