Results 81 to 90 of about 5,946,067 (288)

Immune Modulation Properties of Zoledronic Acid on TcRγδ T-Lymphocytes After TcRαβ/CD19-Depleted Haploidentical Stem Cell Transplantation: An analysis on 46 Pediatric Patients Affected by Acute Leukemia

Frontiers in Immunology, 2020
TcRαβ/CD19-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents a promising new platform for children affected by acute leukemia in need of an allograft and lacking a matched donor, disease recurrence being the
P. Merli, M. Algeri, F. Galaverna, G. Milano, V. Bertaina, Simone Biagini, E. Girolami, G. Palumbo, M. Sinibaldi, M. Becilli, Giovanna Leone, E. Boccieri, L. Grapulin, S. Gaspari, I. Airoldi, L. Strocchio, D. Pagliara, F. Locatelli   +17 more
semanticscholar   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Acute unilateral anterior uveitis following zoledronic acid infusion: A case report

SAGE Open Medical Case Reports, 2020
Bisphosphonates are widely used to treat several clinical conditions. Zoledronic acid is one of this class, commonly used for the treatment and prevention of osteoporosis, hypercalcemia of malignancy, Paget’s disease, and multiple myeloma.
Kiruththihan Anandasayanan, Muthusamy Malaravan, Navaneethakrishnan Suganthan   +2 more
doaj   +1 more source

Lessons learned from long-term side effects after zoledronic acid infusion following denosumab treatment: a case report and review of the literature

Journal of Medical Case Reports, 2022
Background Zoledronic acid is an intravenous, highly potent aminobisphosphonate for use in patients with primary or secondary osteoporosis. Zoledronic acid-induced prolonged side-effects are well known and quite common.
Ilona Nurmi-Lüthje, Peter Lüthje
doaj   +1 more source

Anti-tumour activity of bisphosphonates in preclinical models of breast cancer [PDF]

, 2010
There is increasing evidence of anti-tumour effects of bisphosphonates from pre-clinical studies, supporting a role for these drugs beyond their traditional use in treatment of cancer-induced bone disease.
A Sasaki, A Sasaki, AC Hirbe, AJ Roelofs, C Melani, C Walter, D Santini, D Santini, DW Dempster, ER van Beek, EY Lin, F Daubiné, G Facchini, G Morgan, G Rennert, G van der Pluijm, GR Mundy, GR Mundy, H Eidtmann, H Mönkkönen, H Neville-Webbe, HK Brown, HL Benford, HM Weiss, Ingunn Holen, J Dai, J Soltau, J Wood, J Yamada, JH Lin, JM Tuomela, K Thompson, M Coscia, M Gnant, M Michailidou, M Neudert, MC Winter, MJ Simon, P Clézardin, PA Newcomb, PD Ottewell, PD Ottewell, PD Ottewell, PD Ottewell, PD Ottewell, PI Croucher, PP Provenzano, R Aft, RD Leek, RE Coleman, Robert E Coleman, S Meraviglia, SB Coffelt, SP Luckman, T Bäuerle, T Chen, T Hiraga, T Hiraga, T Hiraga, T Powles, T Ziebart, TL Aghaloo, V Kunzmann, WC Duivenvoorden, X Tang   +64 more
core   +2 more sources

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, EarlyView.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source

Comprehensive evaluation of compound Kushen injection combined with zoledronic acid in treating bone metastasis cancer pain based on meta-analysis and decision tree model

Frontiers in Pain Research
ObjectiveTo evaluate the safety, efficacy, and cost-effectiveness of combining Compound Kushen Injection (CKI) with zoledronic acid in the treatment of bone metastasis-induced cancer pain in malignant tumors.MethodsA comprehensive search of Chinese and ...
Xi Zhao, Tianwei Meng, Kaiqiang Wang, Xi Yan, Yuqiang Liu, Xinghua Li   +5 more
doaj   +1 more source

Oestrogen and zoledronic acid driven changes to the bone and immune environments: Potential mechanisms underlying the differential anti-tumour effects of zoledronic acid in pre- and post-menopausal conditions

Journal of Bone Oncology, 2020
Highlights • Zoledronic acid can prevent recurrence and improve survival when given in early breast cancer.• Anti-cancer effects were only observed in post-menopausal women with confirmed low oestrogen.• We discuss molecular and immune regulated ...
Christopher N. George, Victor Canuas-Landero, Elizavet Theodoulou, M. Muthana, C. Wilson, P. Ottewell   +5 more
semanticscholar   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Journal of Bone and Mineral Research, 2020
Carboplatin is a chemotherapy drug used to treat solid tumors but also causes bone loss and muscle atrophy and weakness. Bone loss contributes to muscle weakness through bone‐muscle crosstalk, which is prevented with the bisphosphonate zoledronic acid ...
Brian A. Hain, B. Jude, Haifang Xu, Dallas Smuin, Edward J. Fox, J. Elfar, David L. Waning   +6 more
semanticscholar   +1 more source