Results 21 to 30 of about 19,753 (208)

Life-threatening hyperkalemia following zoledronic acid infusion for Paget's disease: a case report

Journal of Medical Case Reports, 2011
Introduction Zoledronic acid is a highly effective treatment in Paget's disease for persistent bone pain and prevention of further progression of the disease. The commonest electrolyte abnormality is hypocalcemia. To the best of our knowledge this is the
Naysmith Morag, Young Neil, Panteliou Eleftheria   +2 more
doaj   +1 more source

Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Zoledronic acid, one of the most potent nitrogen-containing biphosphonates, has been demonstrated to have direct anti-tumor and anti-metastatic properties in breast cancer in vitro and in vivo.
Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu, Man-Jiang Xie   +10 more
doaj   +1 more source

Dosing of zoledronic acid with its anti-tumor effects in breast cancer

Journal of Bone Oncology, 2015
Bisphosphonates have played an important role in the treatment of breast cancer, mainly in patients with bone metastasis, by reducing the risk of fracture, spinal cord compression, and hypercalcemia.
Xinmin Zhao, Xichun Hu
doaj   +1 more source

Zoledronic acid in breast cancer: latest findings and interpretations

Therapeutic Advances in Medical Oncology, 2011
The intravenous nitrogen-containing bisphosphonate zoledronic acid has been shown to block multiple steps in tumor metastasis (e.g. angiogenesis, invasion, adhesion, proliferation) in preclinical and translational studies.
Michael Gnant
doaj   +1 more source

Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay

BMC Cancer, 2009
Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients.
Dexel Susanne, Reichelt Ralf, Fernando Augusta, Glaysher Sharon, Kurbacher Christian M, Knight Louise A, Reinhold Uwe, Cree Ian A   +7 more
doaj   +1 more source

Assessment of the Impact of Zoledronic Acid on Ovariectomized Osteoporosis Model Using Micro-CT Scanning. [PDF]

PLoS ONE, 2015
Prompted by preliminary findings, this study was conducted to investigate the impact of zoledronic acid on the cancellous bone microstructure and its effect on the level of β-catenin in a mouse model of postmenopausal osteoporosis.96 8-week-old specific ...
Bo Shuai, Lin Shen, Yanping Yang, Chen Ma, Rui Zhu, Xiaojuan Xu   +5 more
doaj   +1 more source

Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving Gonadotropin-Releasing Hormone Analog

Prostate Cancer, 2011
Background. Loss of bone density with androgen deprivation therapy for prostate cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone mineral density (BMD) and markers of bone turnover over a one-year period ...
Anoop Kapoor, Ankur Gupta, Nilay Desai, Hongshik Ahn   +3 more
doaj   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Zoledronic acid and teriparatide have a complementary therapeutic effect on aseptic loosening in a rabbit model

BMC Musculoskeletal Disorders, 2021
Background Revisions are mainly caused by wear debris-induced aseptic loosening. How to effectively suppress debris-induced periprosthetic osteolysis has become an urgent problem.
Peng Wang, Guang-qian Shang, Shuai Xiang, Hai-ning Zhang, Ying-zhen Wang, Hao Xu   +5 more
doaj   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source