Results 21 to 30 of about 5,946,067 (288)

Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Journal of Experimental & Clinical Cancer Research, 2019
Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear.
Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang, Feng Luo   +7 more
doaj   +2 more sources

Bone loss after denosumab discontinuation is prevented by alendronate and zoledronic acid but not risedronate: a retrospective study

Osteoporosis International, 2023
Summary A retrospective study of 121 patients who stopped denosumab (Dmab) then received no treatment (NT), risedronate (RIS), alendronate (ALN), or zoledronic acid (ZOL).
Teerapat Tutaworn, J. Nieves, Zhaorui Wang, Ju. E. Levin, J. Yoo, J. Lane   +5 more
semanticscholar   +1 more source

Cost-Effectiveness of Sequential Denosumab/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Pharmacology, 2022
Objective: The primary purpose of this study was to estimate the cost-effectiveness of sequential denosumab/zoledronic acid versus zoledronic acid monotherapy for postmenopausal osteoporotic women in China.Methods: We updated and utilized a previously ...
Ruxu You, Jinyu Liu, Lei Ke, Min Wan, Yu Zhang, Guangyi Yu, Takahiro Mori, Takahiro Mori, Takahiro Mori   +8 more
doaj   +1 more source

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Aging, 2023
In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals.
Parinya Samakkarnthai, D. Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, Graham G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, N. LeBrasseur, J. Farr, P. Robbins, S. Khosla   +18 more
semanticscholar   +1 more source

The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]

, 2014
We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hassanein, Mohamed K, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Menen, Rhiana, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Tanaka, Kuniya, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya   +17 more
core   +9 more sources

Cost-Effectiveness of Sequential Teriparatide/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Public Health, 2022
ObjectiveWe aimed to assess the cost-effectiveness of sequential teriparatide/zoledronic acid relative to zoledronic acid monotherapy for postmenopausal osteoporotic women in China.MethodsA previously validated Markov microsimulation model was updated to
Ruxu You, Jinyu Liu, Lei Ke, Guangyi Yu, Yu Zhang, Takahiro Mori, Takahiro Mori, Takahiro Mori   +7 more
doaj   +1 more source

Management of bone metastasis with zoledronic acid: A systematic review and Bayesian network meta-analysis

Journal of Bone Oncology, 2023
Highlights • The outcomes of zoledronic acid were assessed through a Bayesian meta-analysis.• Zoledronic acid reduces the incidence of skeletal-related events and pain.• No statistically significant treatment was found for overall survival.
Justin-Pierre Lorange, J. L. Ramírez García Luna, Frédéric Grou-Boileau, Derek H. Rosenzweig, Michael H. Weber, E. Akoury   +5 more
semanticscholar   +1 more source

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Investigation of Intravenous Zoledronic Acid Therapy on Circulating Lymphocyte Subpopulation in Patients with Primary Osteoporosis: A Pilot Study

Current Therapeutic Research, 2021
: Background: Several studies have investigated the immunomodulating properties of zoledronic acid on T lymphocytes, but the causal relationship between the function of T cells and the efficacy of zoledronic acid has not been elucidated Objective: To ...
Min Cui, Ph. D, Na Zhang, M.Med, Gang Zhang, B. Med, Lei Han, M.Med, Ling Zhi Yu, Ph. D   +4 more
doaj   +1 more source

Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial

Journal of Bone Oncology, 2022
Highlights • Denosumab and zoledronic acid had similar tumor responses and clinical benefits.• Disease progression was observed in patients in the DB group (12.5%) than ZA group (15.0%).• Denosumab treatment was markedly more expensive than zoledronic ...
Jiaji Yue, Wei Sun, Shenglong Li
semanticscholar   +1 more source