Results 61 to 70 of about 22,649 (238)

Endocytotic uptake of zoledronic acid by tubular cells may explain its renal effects in cancer patients receiving high doses of the compound.

open access: yesPLoS ONE, 2015
Zoledronic acid, a highly potent nitrogen-containing bisphosphonate used for the treatment of pathological bone loss, is excreted unmetabolized via the kidney if not bound to the bone.
Anja Verhulst   +3 more
doaj   +1 more source

Ab initio Investigation of Adsorption Characteristics of Bisphosphonates on Hydroxyapatite (001) Surface [PDF]

open access: yesarXiv, 2016
The structures of some bisphosphonates (clodronate, etidronate, pamidronate, alendronate, risedronate, zoledronate, minodronate) were obtained and analyzed, and their adsorption energies onto hydroxyapatite (001) surface were compared to find out ranking order of binding affinity, which shows that the adsorption energy is the largest for pamidronate ...
arxiv  

Fragility fractures in well‐differentiated gastroenteropancreatic neuroendocrine tumors: Results from a multicentered retrospective study

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Patients with gastroenteropancreatic–neuroendocrine tumors (GEP‐NETs) may present skeletal fragility that might be related to multiple factors, including bone metastases, vitamin D deficiency, hormone secretion, and disease treatments. This study examines the prevalence and determinants of fragility fractures in low grading (G1‐G2) GEP‐NETs ...
Alessandro Brunetti   +15 more
wiley   +1 more source

Codelivery of zoledronic acid and double-stranded RNA from core-shell nanoparticles

open access: yesInternational Journal of Nanomedicine, 2013
Li Chen,1 Yunfei Ding,2 Yongzhong Wang,3 Xingrong Liu,2 RJ Babu,1 WR Ravis,1 Weili Yan21Department of Pharmaceutical Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA; 2Department of Pharmaceutical Sciences, College of Life ...
Yan W   +6 more
doaj  

Carbon Doping of MgB2 by Toluene and Malic-Acid-in-Toluene [PDF]

open access: yes, 2010
The decomposition of malic acid in the presence of Mg and B was studied using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) which revealed that malic acid reacted with Mg but not B. Also, the addition of toluene to dissolve malic acid followed by subsequent drying resulted in no reaction with Mg, indicating that the malic
arxiv   +1 more source

Cancer treatment and survivorship statistics, 2025

open access: yesCA: A Cancer Journal for Clinicians, EarlyView.
Abstract The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National ...
Nikita Sandeep Wagle   +9 more
wiley   +1 more source

Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells.

open access: yesPLoS ONE, 2015
While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we investigated the response to ...
Tamás Garay   +13 more
doaj   +1 more source

Acid zeta function and ajoint acid zeta function [PDF]

open access: yesarXiv, 2010
In this paper we set up the theory of acid zeta function and ajoint acid zeta function, based on the theory, we point out a reason to doubt the truth of the Riemann hypothesis and also as a consequence, we give out some new RH equivalences.
arxiv  

A search for mid-IR bands of amino acids in the Perseus Molecular Cloud [PDF]

open access: yesarXiv, 2021
Amino acids are building-blocks of proteins, basic constituents of all organisms and essential to life on Earth. They are present in carbonaceous chondrite meteorites and comets, but their origin is still unknown. Formation of amino acids in the interstellar medium is posible via specific gas-phase reactions in dark clouds, however sensitive ...
arxiv  

Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial

open access: yesInternational Journal of Cancer, Volume 156, Issue 11, Page 2178-2187, 1 June 2025.
What's new? Bone metastases are common in a variety of cancer types, causing increased pain and worse outcomes. Suppression of bone turnover, such as with the monoclonal antibody denosumab, results in fewer skeletal complications and improved prognosis. Here, the authors demonstrate the safety and efficacy of a similar antibody, JMT103. Like denosumab,
Ran Ran   +15 more
wiley   +1 more source

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