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The fate of the zona pellucida in mice
Development, 1970ABSTRACT In mice and rats, the egg is surrounded by a mucoprotein coat, the zona pellucida, which is lost shortly before implantation. The mechanism of loss has long been a matter of controversy. In rats, loss of the zona has variously been reported to be by lysis (Defrise, 1933; Dickson, 1963) or by an active hatching mechanism ...
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Antibody reactivity with porcine zona pellucida
Journal of Reproductive Immunology, 1985A comparative study on anti-zona antibody activities in the sera from clinically defined categories of patients registered at the WHO Reference Bank for Reproductive Immunology was performed at five different laboratories with different detection methods.
T, Mori +8 more
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Mouse zona pellucida genes and glycoproteins
Cytogenetic and Genome Research, 2004The zona pellucida (ZP) is a thick extracellular coat that surrounds all mammalian eggs. The ZP plays important roles during oogenesis, fertilization, and preimplantation development. The mouse ZP consists of only three glycoproteins, called ZP1, ZP2, and ZP3. All three glycoproteins are essential structural components of the ZP.
P M, Wassarman, L, Jovine, E S, Litscher
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The Potential of the Zona Pellucida as a Target for Immunocontraception
American Journal of Reproductive Immunology, 1996PROBLEM: To investigate the contraceptive potential of the zona pellucida. METHOD: Generation of antibodies against native and recombinant zona glycoproteins which have then been assessed for their capacity to disrupt sperm‐zona interaction in vivo and in vitro.
R J, Aitken, M, Paterson, M, van Duin
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Immunological specificity of anti‐zona binding to zona pellucida
Journal of Experimental Zoology, 1978AbstractBiochemically purified and F(ab′)2 immunoglobulin fractions were prepared from several antisera, including a human serum, which contained anti‐zona pellucida activity. Antizona activity was monitored either by the formation of the antibody produced precipitation layer on the zona following antiserum treatment and/or by the indirect fluorescent ...
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The Human Egg's Zona Pellucida
2018Human zona pellucida (ZP) matrix, a delicate network of thin interconnected filaments, is primarily composed of four glycoproteins, namely, ZP1, ZP2, ZP3, and ZP4. All four zona proteins share common structural elements such as signal peptide, "ZP domain," consensus furin cleavage site, transmembrane-like domain, and short cytoplasmic tail. In addition,
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Autoantibodies to zona pellucida in tubectomized women
Contraception, 1984khe study was conducted to detect autoantibodies to zona pellucida by indirect immunofluorescence technique. A total of 60 human sera was examined, which included 15 tubectomized , 15 pregnant, 15 nonpregnant fertile women, and 15 fertile men. In the unabsorbed sera, anti-zona activity was observed in 53.3% of the tubectomized women and in 40.0% of the
A, Mhaskar, K, Buckshee, G P, Talwar
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The Action of Acrosin on the Zona Pellucida
1986The presence of hydrolytic enzymes in and associated with the sperm head has long argued for their functioning in fertilization. Several observations led investigators to propose that the acrosomal trypsin-like enzyme, acrosin in mammals, functioned in fertilization in aiding the sperm to penetrate the zona pellucida. While many have raised significant
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Structure of Zona Pellucida Module Proteins
2018The egg coat, an extracellular matrix made up of glycoprotein filaments, plays a key role in animal fertilization by acting as a gatekeeper for sperm. Egg coat components polymerize using a common zona pellucida (ZP) "domain" module that consists of two related immunoglobulin-like domains, called ZP-N and ZP-C. The ZP module has also been recognized in
Marcel Bokhove, Luca Jovine
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The zona pellucida: A coat of many colors
BioEssays, 1987AbstractThe zona pellucida is an extracellular coat that surrounds all mammalian eggs. It is a porous matrix of interconnected filaments that are assembled from glycoproteins synthesized and secreted by growing oocytes. The zona pellucida is responsible both for species‐specific binding of sperm to unfertilized eggs and inducing bound sperm to undergo ...
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