Results 11 to 20 of about 21,302 (208)

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Silencing Zonula occludens 2 (ZO-2), a tight junctions (TJ) scaffold protein, in epithelial cells (MDCK ZO-2 KD) triggers: 1) Decreased cell to substratum attachment, accompanied by reduced expression of claudin-7 and integrin β1, and increased vinculin recruitment to focal adhesions and stress fibers formation; 2) Lowered cell-cell aggregation and ...
Raya-Sandino, A., Castillo-Kauil, A., Domínguez-Calderón, A., Alarcón, L., Flores-Benitez, D., Cuellar-Perez, F., López-Bayghen, B., Chávez-Munguía, B., Vázquez-Prado, J., González-Mariscal, L.   +9 more
openaire   +4 more sources

Fuzi polysaccharides improve immunity in immunosuppressed mouse models by regulating gut microbiota composition

Heliyon, 2023
Rationale and objectives: Fuzi, the dried root of Aconitum carmichaelii Debx, is one of the widely used traditional Chinese medicines. Fuzi polysaccharides are considered the most bioactive compounds with immunomodulatory functions, however, the ...
Ran Tu, Cheng Zhou, Wenfeng Huang, Zhengping Feng, Qiufang Zhao, Xiaofei Shi, Langjun Cui, Keke Chen   +7 more
doaj   +1 more source

Astragalus polysaccharides and astragaloside IV ameliorates cyclophosphamide-induced mouse model of overactive bladder

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: Previous studies have shown that Astragalus polysaccharides (APS) and Astragaloside IV (AS-IV) protect against inflammation-related cell damage and exhibit immune enhancement.
Yung-Hsiang Chen, Wen-Chi Chen, Po-Len Liu, Huey-Yi Chen   +3 more
doaj   +1 more source

Effect of Glucagon-like Peptide 2 on Tight Junction in Jejunal Epithelium of Weaned Pigs though MAPK Signaling Pathway [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
The glucagon-like peptide 2 (GLP-2) that is expressed in intestine epithelial cells of mammals, is important for intestinal barrier function and regulation of tight junction (TJ) proteins. However, there is little known about the intracellular mechanisms
Changsong Yu, Gang Jia, Yi Jiang, Qiuhong Deng, Zhengli Chen, Zhiwen Xu, Xiaolin Chen, Kangning Wang   +7 more
doaj   +1 more source

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds.
Jingbo Jiang, Daniel Hoagland, Joseph A. Palatinus, Huamei He, Jegan Iyyathurai, L. Jane Jourdan, Geert Bultynck, Zhen Wang, Zhiwei Zhang, Kevin Schey, Steven Poelzing, Francis X. McGowan, Robert G. Gourdie   +12 more
doaj   +1 more source

Supplementation of postbiotic RI11 improves antioxidant enzyme activity, upregulated gut barrier genes, and reduced cytokine, acute phase protein, and heat shock protein 70 gene expression levels in heat-stressed broilers

Poultry Science, 2021
The aim of this work was to evaluate the impacts of feeding different levels of postbiotic RI11 on antioxidant enzyme activity, physiological stress indicators, and cytokine and gut barrier gene expression in broilers under heat stress.
Ali Merzza Humam, Teck Chwen Loh, Hooi Ling Foo, Wan Ibrahim Izuddin, Idrus Zulkifli, Anjas Asmara Samsudin, Noordin Mohamed Mustapha   +6 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis

International Journal of Immunopathology and Pharmacology, 2020
Emodin is an effective component in rhubarb to cure intestinal dysfunction, but the specific mechanism remains unknown. This study aimed to evaluate the protective effects of emodin on intestinal dysfunction caused by acute severe pancreatitis and reveal
Yang Tan, Wei Zhang, Hai-ying Wu, Jing Xia, Huang-bo Zhang, Ming-wei Liu, Chuan-yun Qian   +6 more
doaj   +1 more source

The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density [PDF]

, 2003
Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral intramembrane diffusion of lipids, and have been proposed to participate in the control of epithelial cell proliferation and differentiation.
Balda, MS, Matter, K, Karl Matter, Garrett, MD, Michelle D. Garrett, Maria S. Balda   +5 more
core   +1 more source

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis

Gastroenterology Research and Practice, 2021
Curcumin is a natural polyphenol and is supposed to possess antioxidant, anti-inflammatory, anticancer, and antiapoptotic properties. Although some studies have reported the therapeutic effects of curcumin on ulcerative colitis (UC), the specific ...
Xinxin Zhou, Mengting Ren, Jinpu Yang, Hanghai Pan, Mosang Yu, Feng Ji   +5 more
doaj   +1 more source