Results 21 to 30 of about 60,948 (246)

Evaluation of different 89Zr-labeled synthons for direct labeling and tracking of white blood cells and stem cells in healthy athymic mice

Scientific Reports, 2022
Cell based therapies are evolving as an effective new approach to treat various diseases. To understand the safety, efficacy, and mechanism of action of cell-based therapies, it is imperative to follow their biodistribution noninvasively.
Aditya Bansal, Shalini Sharma, Benedikt Klasen, Frank Rösch, Mukesh K. Pandey   +4 more
doaj   +1 more source

Interdiffusion in Zr-Mo/W Intermetallics

Applied Sciences, 2023
Intermetallic compounds or solid solutions can form between Zr and Mo/W, in which the multiphase of the diffusion may be influenced by each other. Interdiffusion kinetic data in such intermetallic systems are highly demanded for material design.
Kaihua Wang, Xingwei Liu, Tianyu Liu, Chuan He, Jinxu Liu   +4 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Effect of Zr on microstructure and properties of TC4 alloy fabricated by laser additive manufacturing

Journal of Materials Research and Technology, 2023
In this paper, the effect of Zr on the microstructure of laser additive manufactured Ti–6Al–4V (TC4) alloy is studied by adding different contents of Zr (0%, 15%, 30%, 45%), and the mechanisms of strengthening and corrosion passivation are also discussed.
X.J. Jiang, S.J. Bao, L.W. Zhang, X.Y. Zhang, L.S. Jiao, H.B. Qi, F. Wang   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Stress Distribution on Bone Due to Dental Implant

Journal of Pharmacy and Bioallied Sciences
Background: The distribution of stress (DS) in the bone around dental implant (DI) during loading is associated with success. In contrast, upon loosening of DI because of high stress, leads to its failure.
Ajay Gaikwad, Lishoy W Rodrigues, Karuna Gajanan Pawashe, Praveen Gangadharappa, Amit Bajirao Jadhav, Shruti Dabi   +5 more
doaj   +1 more source

Recent Advances in the Grain Refinement Effects of Zr on Mg Alloys: A Review

Metals, 2022
As the lightest structural materials, Mg alloys show great effectiveness at energy saving and emission reduction when applied in the automotive and aerospace fields.
Ming Sun, Depeng Yang, Yu Zhang, Lin Mao, Xikuo Li, Song Pang   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source