Results 51 to 60 of about 5,798 (171)

Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance

MedComm, Volume 6, Issue 11, November 2025.
This graphical abstract illustrates the immunomodulation of chronic wounds through various therapeutic approaches aimed at regulating the immune response to promote healing. ABSTRACT Chronic wounds—such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)—pose a serious clinical challenge due to their prolonged ...
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar, Thomas Biedermann   +3 more
wiley   +1 more source

Active Anthocyanin Degradation in Solanum macranthum Flowers Involves Both Peroxidase and β‐Glucosidase Enzymes

Physiologia Plantarum, Volume 177, Issue 6, November/December 2025.
ABSTRACT Anthocyanin coloration of fruit, foliage, and flowers is dependent both on pigment synthesis and degradation. Our previous comprehensive study on in planta anthocyanin degradation was conducted on the purple Brunfelsia calycina flowers, whitening due to a one‐step process, involving a single vacuolar peroxidase.
Stalin Nadarajan, Varun Kumar, Rinat Ovadia, Anita Kumari, Adi Doron‐Faigenboim, Bipin Singh, Michal Oren‐Shamir   +6 more
wiley   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Endolysin Expression, Purification and Activity Determination by Zymography

Bio-Protocol, 2014
Endolysins are peptidoglycan-degrading (muralytic) enzymes produced by many bacteriophages for cell lysis of the host bacterium. The enzymatic activity of muralytic enzymes can be assayed qualitatively using a zymogram containing incorporated ...
Alexander Westbye, Paul Fogg, John Beatty   +2 more
doaj   +1 more source

Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague–Dawley rats

Physiological Reports, Volume 13, Issue 19, October 2025.
Abstract In the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress‐induced changes.
D. Sztechman, T. Zera, K. Czarzasta, E. Szczepanska‐Sadowska, A. Cudnoch‐Jedrzejewska   +4 more
wiley   +1 more source

Tumoural Hypoxic Extracellular Vesicles Foster a Protective Microenvironment in Triple‐Negative Breast Cancer

Journal of Extracellular Biology, Volume 4, Issue 9, September 2025.
ABSTRACT The highly metastatic triple‐negative breast cancer (TNBC) relies on the tumour microenvironment (TME) to maintain phenotypic heterogeneity and progression. Extracellular vesicles from hypoxic TNBC (EVh) have been previously shown to facilitate tumoural invasion; however, their function in the TME remains unclear.
Bianca Cruz Pachane, Pedro Henrique Teixeira Bottaro, Aline Maria Machado, Cynthia Aparecida de Castro, Gabriela Guerra, Larissa Thabata Gozzer, Marina Mantellatto Grigoli, Arthur Deponte Zutião, Angelina Maria Fuzer, Marcia Regina Cominetti, Wanessa Fernanda Altei, Heloisa Sobreiro Selistre‐de‐Araujo   +11 more
wiley   +1 more source

Zymogram Analysis in Brassica Species

Japanese Journal of Breeding, 1983
Studies were carried out to consider from the viewpoint of isozyme analysis some genetical relationships among Brassica genome types and to examine whether the isozyme method could be applied in identifying hybrids at an early stage of growth. Several varieties were selected from each Brassica genome type.
openaire   +2 more sources

Efficacy and Safety of Second‐Line Immune Checkpoint Inhibitor Rechallenge in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study

Thoracic Cancer, Volume 16, Issue 13, July 2025.
Zhao et al. demonstrate the efficacy, survival and safety of second‐line immune checkpoint inhibitor rechallenge in advanced or metastatic esophageal squamous cell carcinoma patients. This provides a potential therapy option of second‐line treatment for esophageal squamous cell carcinoma patients after first‐line immunotherapy failure.
Wensi Zhao, Nan Zhao, Dedong Cao
wiley   +1 more source

Downregulation of Alox5 Inhibits Ferroptosis to Improve Doxorubicin‐Induced Cardiotoxicity via the P53/SLC7A11 Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Doxorubicin (DOX) is an anthracycline chemotherapeutic drug used for tumour treatment. Due to DOX‐induced cardiotoxicity (DIC), its clinical application has been widely limited. Multiple studies have shown that ferroptosis is involved in the pathogenesis of DIC and that arachidonate 5‐lipoxygenase (Alox5) plays an important role in the ...
Wenxi Fang, Zhefu Hu, Bo Shen, Xiaofeng Zeng, Si Chen, Shasha Wang, Saiyang Xie, Wei Deng   +7 more
wiley   +1 more source

Purification and Characterization of Alkaline Metalloprotease from Bacillus sp. MTCC 9558 and its Application in Bioactive Peptide Production

Journal of Pure and Applied Microbiology, 2017
The present study describes the protease purification from halophilic Bacillus sp. MTCC 9558 by a single step hydrophobic interaction chromatographic using Phenyl-Sepharose CL - 4B column.
Roopa Prasad, Ananthakrishnan Jayakumaran Nair, Theruvath Koshy Abraham   +2 more
doaj   +1 more source