Results 91 to 100 of about 40,088 (308)

D-Galactosamine Causes Liver Injury Synergistically with Lipopolysaccharide but not Zymosan in Chicks

The Journal of Poultry Science, 2023
The pathogen-associated molecular patterns (PAMPs) lipopolysaccharide (LPS) and zymosan, derived from gram-negative bacteria and fungi, respectively, activate the innate immune system and cause injury to multiple organs, including the liver and intestine,
Maki Takahashi, Akira Senga, Kei Teraoka, Sakirul Khan, Ryosuke Makino, Mark A. Cline, Tetsuya Tachibana   +6 more
doaj   +1 more source

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

Journal of Clinical Investigation, 2006
Emerging evidence suggests critical roles for APCs in suppressing immune responses. Here, we show that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance.
S. Dillon, S. Agrawal, K. Banerjee, J. Letterio, T. Denning, Kyra A. Oswald-Richter, Deborah J. Kasprowicz, K. Kellar, Jeff Pare, T. V. Van Dyke, S. Ziegler, D. Unutmaz, B. Pulendran   +12 more
semanticscholar   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.
This mini‐review summarizes different classes of pattern recognition receptors (PRRs) and the role of their agonizts that have been identified and also outlines the role of PRR ligands as immunostimulatory molecules. Overall, the mini‐review has elaborated on the role of PRRs in the development of therapeutic vaccine adjuvants.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
wiley   +1 more source

Pathobiology and Regulation of Eosinophils, Mast Cells, and Basophils in Allergic Asthma

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Eosinophilia is a hallmark of allergic disorders, including asthma, allergic rhinitis, and atopic dermatitis. The onset and maintenance of allergic inflammation in atopic adults involves the activation of selective hemopoietic processes and the migration of mature and immature eosinophils to allergic tissue, where these cells release mediators
Christiane E. Whetstone, Rand Amer, Samarah Maqbool, Tooba Javed, Gail M. Gauvreau   +4 more
wiley   +1 more source

Inflammation and enhanced nociceptive responses to bladder distension produced by intravesical zymosan in the rat

BMC Urology, 2006
Background Mycotic infections of the bladder produce pain and inflammatory changes. The present study examined the inflammatory and nociceptive effects of the yeast cell wall component, zymosan, when admininstered into the urinary bladder in order to ...
Cannon Ronda, Uzzell Tyler, Randich Alan, Ness Timothy J   +3 more
doaj   +1 more source

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]

, 2019
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J, Cleuren, Audrey C, Czepielewski, Rafael S, Edelson, Brian T, Erlich, Emma C, Esaulova, Ekaterina, Grover, Steven P, Jarjour, Nicholas N, Mackman, Nigel, Randolph, Gwendalyn J, Saunders, Brian T, Zhang, Nan, Zinselmeyer, Bernd H   +12 more
core   +1 more source

Zymosan as a Possible Reagent in Local Shwartzman Reaction

Experimental Biology and Medicine, 1959
SummaryTo investigate the possibility of zymosan's tumor-necrotizing activity in mice being mediated through a modification of the Shwartzman reaction, the mouse strain in which the phenomenon has been studied, was examined for its capacity to display the Shwartzman reaction when tested with competent bacterial endotoxin.
William T. Bradner, Howard A. Schneider, William F. Arndt   +2 more
openaire   +3 more sources

Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood

Scandinavian Journal of Immunology, Volume 101, Issue 5, May 2025.
Complement inhibition (factor D, C3, C5, or C5aR1) blunts inflammation induced by Escherichia coli or Aspergillus fumigatus conidia in lepirudin‐treated whole blood. Inhibition decreases inflammatory markers, reduces anaphylatoxin receptor expression, and lowers cytokine production and phagocytic activity. Created in https://BioRender.com.
Leon Cyranka, Ida Mariegaard, Beatrice Fageräng, Laura Pérez‐Alós, Verena Harpf, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +7 more
wiley   +1 more source

Role of PPAR-δ in the development of zymosan-induced multiple organ failure: an experiment mice study

Journal of Inflammation, 2010
Background Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a nuclear receptor transcription factor that regulates gene expression in many important biological processes. It is expressed ubiquitously, especially white adipose tissue, heart,
Kapoor Amar, Bramanti Placido, Cuzzocrea Elisabetta, Paterniti Irene, Crisafulli Concetta, Genovese Tiziana, Mazzon Emanuela, Di Paola Rosanna, Galuppo Maria, Thiemermann Christoph, Cuzzocrea Salvatore   +10 more
doaj   +1 more source

Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation [PDF]

, 2004
Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified.
Barger, Mark, Boegehold, Matthew A., Castranova, Vincent, Nurkiewicz, Timothy R., Porter, Dale W.   +4 more
core   +3 more sources