Results 101 to 110 of about 40,088 (308)

Alzheimer's Disease Risk Gene SORL1 Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli

Glia, Volume 73, Issue 4, Page 857-872, April 2025.
Main Points SORLA directs CD14 to the cell surface, sensitizing microglia to inflammatory stimuli. SORLA activity in microglia may play an important role in shaping the inflammatory environment of the brain. ABSTRACT Sorting protein‐related receptor containing class A repeats (SORLA) is an intracellular trafficking receptor encoded by the Alzheimer's ...
Peter Lund Ovesen, Kristian Juul‐Madsen, Narasimha S. Telugu, Vanessa Schmidt, Silke Frahm, Helena Radbruch, Emma Louise Louth, Anders Rosendal Korshøj, Frank L. Heppner, Sebastian Diecke, Helmut Kettenmann, Thomas E. Willnow   +11 more
wiley   +1 more source

Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.

PLoS ONE, 2013
In response to infection by fungal pathogens, the innate immune system recognises specific fungal pathogen associated molecular patterns (PAMPs) via pattern recognition receptors including the C-type lectin dectin-1 and members of the Toll Like Receptor (
Suzanne E Elcombe, Shaista Naqvi, Mirjam W M Van Den Bosch, Kirsty F MacKenzie, Francesca Cianfanelli, Gordon D Brown, J Simon C Arthur   +6 more
doaj   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
core  

Antioxidative effects of α-lipoic acid in the brain, liver and kidneys in selected mouse organs exposed to zymosan [PDF]

, 2015
This study investigated the role of exogenous α-lipoic acid (ALA) in the inflammation caused by zymosan application. Seventy-two adult male white mice were divided into twelve groups: three control groups, three Zymosan groups, three ALA groups and three
Dziubek, Karol, Goc, Zofia, Greń, Agnieszka, Kapusta, Edyta, Szaroma, Waldemar   +4 more
core   +1 more source

Yersinia pestis Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils

Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
Typically, neutrophils respond to invading pathogens by altering the cargo packaged into EVs and increasing EV release, which enhances antimicrobial responses. However, we show here that the bacterial pathogen Yersinia pestis injects Yop effector proteins into neutrophils to actively inhibit EV biogenesis, resulting in limited EV release and ...
Katelyn R. Sheneman, Timothy D. Cummins, Michael L. Merchant, Joshua L. Hood, Silvia M. Uriarte, Matthew B. Lawrenz   +5 more
wiley   +1 more source

Zymosan phagocytosis by mouse peritoneal macrophages is increased by apoHDL- and not by intact HDL-covered particles

Brazilian Journal of Medical and Biological Research, 2000
The uptake of lipids and lipoprotein particles by macrophages undergoes phagocytic activation and the formation of foam cells are key events in atherosclerosis.
M.D.T. Carvalho, V.E. Tobias, C.M.V. Vendrame, A.F.M. Shimabukuro, M. Gidlund, E.C.R. Quintão   +5 more
doaj   +1 more source

Granulocyte-activating mediators (GRAM) [PDF]

, 1988
In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A., Möller, A., Putz, Reinhard, Zeck-Kapp, G.   +3 more
core   +1 more source

The Peptide PROTAC Modality: A New Strategy for Drug Discovery

MedComm, Volume 6, Issue 4, April 2025.
Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley   +1 more source

ROLE OF 5-LIPOXYGENASE IN THE MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN. [PDF]

, 2004
Objective: This study investigated the role of 5-lipoxygenase in the pathogenesis of multiple organ failure (MOF) induced by zymosan. Design: Male mice with a targeted disruption of the 5-lipoxygenase gene (5-LOKO) and littermate wild-type (WT) controls (
BRITTI D., CAPUTI A.P., CUZZOCREA S., DE SARRO A., DI PAOLA R., DUGO L., GENOVESE T., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SCIARRA G., SERRAINO I.   +10 more
core   +1 more source

Proteoglycans and Hyaluronan in Normal and Aberrant Lung Development

Proteoglycan Research, Volume 3, Issue 2, April 2025.
ABSTRACT Lung development is a tightly regulated process that progresses through five distinct stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Each stage is characterized by coordinated cellular interactions and structural changes driven by signals from epithelial, endothelial, and mesenchymal cells.
Andrea Reszegi, Gabor Petovari, Nikitha Damisetty, Stavros Garantziotis, Rashmin C. Savani   +4 more
wiley   +1 more source