Results 11 to 20 of about 32,279 (227)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]

, 2012
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
A Orvedahl, A Schaap-Nutt, A Skaletskaya, AL McCormick, C Mack, C Menard, Carlos A. Guzmán, CE Patterson, D Arnoult, D Lembo, HG Burgert, I Jurak, J Bertin, JL Davignon, JW Upton, L Cicin-Sain, L Cicin-Sain, Linda Ebermann, LK Hanson, Luka Čičin-Šain, M Chaumorcel, M Reboredo, Michele Barry, MJ Reddehase, ML Nguyen, N van Rooijen, N van Rooijen, N van Rooijen, Nico van Rooijen, P Lucin, PM Fliss, Rosaely Casalegno-Garduño, S Hamano, Ulrich Koszinowski, VS Goldmacher, W Brune, W Brune, WJ Kaiser, Zsolt Ruzsics   +38 more
core   +16 more sources

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Cells, 2023
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain.
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay   +10 more
doaj   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation [PDF]

, 2002
Background/Aim: The generation of reactive oxygen species by activated Kupffer cells (KC) may contribute to reperfusion injury of the liver during liver transplantation or resection.
Baron, A., Bilzer, M., Ebensberger, S., Gerbes, Alexander L., Schauer, R., Steib, C.   +5 more
core   +1 more source

Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. [PDF]

, 1984
We have determined the effect of various endocytic ligands on the secretion of ApoE by macrophages. ApoE was a major secreted protein of resident macrophages, but BCG-activated macrophages secreted little ApoE and periodate-elicited macrophages secreted ...
Takemura, R, Werb, Z
core   +2 more sources

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice

Journal of Inflammation, 2018
Background Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments.
Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen, Ian M. Adcock   +8 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy

Molecules, 2019
Complement (C) activation can underlie the infusion reactions to liposomes and other nanoparticle-based medicines, a hypersensitivity syndrome that can be partially reproduced in animal models.
László Dézsi, Tamás Mészáros, Erik Őrfi, Tamás G. Fülöp, Mark Hennies, László Rosivall, Péter Hamar, János Szebeni, Gábor Szénási   +8 more
doaj   +1 more source

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin [PDF]

, 2020
Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction ...
Bäumler, Hans, Georgieva, Radostina, Kao, Ijad, Pruß, Axel, Suwannasom, Nittiya   +4 more
core   +1 more source