Results 21 to 30 of about 40,088 (308)

Preliminary study of the toxicity and radioprotective effects of zymosan in vitro and in vivo

BMC Pharmacology and Toxicology, 2021
Background This study aimed to confirm the cytotoxicity of zymosan in vitro and in vivo and determine the appropriate treatment time and the dose of zymosan. Methods AHH-1 cells and HIECs were administered by 0, 20, 40, 80 or 160 μg/mL zymosan. The CCK-8
Yue-zhi Zhang, Shu-jing Ge, Qing-zhen Leng, Jian-jun Ma, Han-chen Liu   +4 more
doaj   +1 more source

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]

, 2012
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
A Orvedahl, A Schaap-Nutt, A Skaletskaya, AL McCormick, C Mack, C Menard, Carlos A. Guzmán, CE Patterson, D Arnoult, D Lembo, HG Burgert, I Jurak, J Bertin, JL Davignon, JW Upton, L Cicin-Sain, L Cicin-Sain, Linda Ebermann, LK Hanson, Luka Čičin-Šain, M Chaumorcel, M Reboredo, Michele Barry, MJ Reddehase, ML Nguyen, N van Rooijen, N van Rooijen, N van Rooijen, Nico van Rooijen, P Lucin, PM Fliss, Rosaely Casalegno-Garduño, S Hamano, Ulrich Koszinowski, VS Goldmacher, W Brune, W Brune, WJ Kaiser, Zsolt Ruzsics   +38 more
core   +15 more sources

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Curdlan, zymosan and a yeast-derived β-glucan reshape tumor-associated macrophages into producers of inflammatory chemo-attractants

Cancer Immunology and Immunotherapy, 2020
Anti-cancer T-cell responses are often halted due to the immune-suppressive micro-environment, in part related to tumor-associated macrophages. In the current study, we assessed indigestible β-glucans (oatβG, curdlan, grifolan, schizophyllan, lentinan ...
Priscilla de Graaff, C. Berrevoets, Christiane Rӧsch, H. Schols, K. Verhoef, H. Wichers, R. Debets, C. Govers   +7 more
semanticscholar   +1 more source

Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan

Marine Drugs, 2023
Fucans from marine algae have been the object of many studies that demonstrated a broad spectrum of biological activities, including anti-inflammatory effects. The aim of this study was to verify the protective effects of a fucan extracted from the brown
Ana Katarina Andrade Silva, Cássio Ricardo de Medeiros Souza, Hylarina Montenegro Diniz Silva, Jéssica Teixeira Jales, Lucas Alves de Souza Gomez, Ericka Janine Dantas da Silveira, Hugo Alexandre Oliveira Rocha, Janeusa Trindade Souto   +7 more
doaj   +1 more source

Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2

Cell Death and Disease, 2022
Intestinal stem cells (ISCs) are responsible for intestinal tissue homeostasis and are important for the regeneration of the damaged intestinal epithelia. Through the establishment of ionizing radiation (IR) induced intestinal injury model, we found that
Jicong Du, Lan Fang, Jianpeng Zhao, Yike Yu, Zhenlan Feng, Yuedong Wang, Ying Cheng, Bailong Li, Fu Gao, Cong Liu   +9 more
doaj   +1 more source

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Cells, 2023
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain.
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay   +10 more
doaj   +1 more source

Downregulation of neutrophil CD43 by opsonized zymosan [PDF]

Blood, 1995
Abstract CD43, a prevalent white blood cell molecule distinguished by its mucin- like surface region, has been proposed as a “functional barrier” that prevents or negatively regulates a variety of cell surface interactions. Implicit in this hypothesis is the expectation that CD43 will be altered or removed when white blood cells are ...
David Parent, Eileen Remold-O'Donnell
openaire   +4 more sources

Phagocytosis of zymosan by human neutrophils [PDF]

Carlsberg Research Communications, 1984
A rapid cellular response occurs when human neutrophils are challenged with the zymosan particle. Monolayers of neutrophils adhering to glass were incubated with opsonized zymosan at 37°C for 15 sec to 3 min, fixed and prepared for observation by SEM, immunofluorescence or TEM.
Edith K. MacRae, Katherine B. Pryzwansky
openaire   +2 more sources