Results 71 to 80 of about 32,279 (227)

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]

, 2019
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J, Cleuren, Audrey C, Czepielewski, Rafael S, Edelson, Brian T, Erlich, Emma C, Esaulova, Ekaterina, Grover, Steven P, Jarjour, Nicholas N, Mackman, Nigel, Randolph, Gwendalyn J, Saunders, Brian T, Zhang, Nan, Zinselmeyer, Bernd H   +12 more
core   +1 more source

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]

, 2013
Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V., Bratton, Donna L., Brown, Gordon D., Gow, Neil A. R., Leslie, Christina C., Mahaffey, Spencer, Murphy, Robert C., Silveira, Lori J., Suram, Saritha, Williams, David L.   +9 more
core   +5 more sources

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance

Advanced Science, Volume 12, Issue 46, December 11, 2025.
β‐glucan‐induced trained immunity reprograms macrophages toward hyperinflammation, exacerbating inflammatory arthritis. In a collagen‐induced arthritis model, trained macrophages intensify disease severity and confer ferroptosis resistance in synovial cells via IL‐1β/NAT10‐mediated FSP1 mRNA modification.
Haibo Su, Baoying Zhang, Qiudi Deng, Jiaxin Huang, Jinyu Feng, Yuan Fu, Yuejun Huang, Weikun Deng, YingJun Su, Huisheng Liu, Ning‐yi Shao, Zhenhui Zhang, Jianwei Dai   +12 more
wiley   +1 more source

Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]

, 1996
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD, Gustavsson, M, Majeed, M, Sanan, DA, Stendahl, O, Zimmerli, S   +5 more
core   +2 more sources

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Mathieson, PW, Oliveria, DB, Peters, DK, Würzner, R   +4 more
core   +1 more source

Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi‐omic studies, but effective prioritization remains a major bottleneck. METHODS We applied an integrative screening framework to assess 29 candidate targets from risk‐enriched biological ...
Gregory A. Cary, Qianjin Li, Jesse C. Wiley, Carolyn A. Paisie, Yuhong Du, Elizabeth L. Zoeller, Duc Duong, Haian Fu, Nicholas T. Seyfried, Allan I. Levey, Ranjita Betarbet, Gregory W. Carter, for The Emory‐Sage‐SGC‐JAX TREAT‐AD Center   +12 more
wiley   +1 more source

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of β2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Anderson, Boyle, Boyle, Chen, Chen, Doerschuk, Fisher, Franke, Gao, Grommes, Hoyal, Kielland, Kulkarni, Liu, Matthay, McMillan, Mócsai, Pollock, Segal, Segal, Segal, Zhang, Zhang, Zhang   +23 more
core   +3 more sources

Role of PPAR-δ in the development of zymosan-induced multiple organ failure: an experiment mice study

Journal of Inflammation, 2010
Background Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a nuclear receptor transcription factor that regulates gene expression in many important biological processes. It is expressed ubiquitously, especially white adipose tissue, heart,
Kapoor Amar, Bramanti Placido, Cuzzocrea Elisabetta, Paterniti Irene, Crisafulli Concetta, Genovese Tiziana, Mazzon Emanuela, Di Paola Rosanna, Galuppo Maria, Thiemermann Christoph, Cuzzocrea Salvatore   +10 more
doaj   +1 more source

Zymosan phagocytosis by mouse peritoneal macrophages is increased by apoHDL- and not by intact HDL-covered particles

Brazilian Journal of Medical and Biological Research, 2000
The uptake of lipids and lipoprotein particles by macrophages undergoes phagocytic activation and the formation of foam cells are key events in atherosclerosis.
M.D.T. Carvalho, V.E. Tobias, C.M.V. Vendrame, A.F.M. Shimabukuro, M. Gidlund, E.C.R. Quintão   +5 more
doaj   +1 more source