Results 11 to 20 of about 252,333 (374)

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

PLoS ONE, 2022
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin, Jessica E Hammond, Lauren Owens, Matthew D Hodges   +3 more
doaj   +1 more source

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers [PDF]

Journal of Biological Chemistry, 2009
The amyloid precursor protein (APP) is implied both in cell growth and differentiation and in neurodegenerative processes in Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide.
Gralle, M., Gralle Botelho, M., Wouters, F.   +2 more
openaire   +5 more sources

Altered processing of amyloid precursor protein in cells undergoing apoptosis. [PDF]

PLoS ONE, 2013
Altered proteolysis of amyloid precursor protein is an important determinant of pathology development in Alzheimer's disease. Here, we describe the detection of two novel fragments of amyloid precursor protein in H4 neuroglioma cells undergoing apoptosis.
Tina Fiorelli, Lisa Kirouac, Jaya Padmanabhan   +2 more
doaj   +1 more source

AMYPdb: A database dedicated to amyloid precursor proteins [PDF]

BMC Bioinformatics, 2008
Abstract Background Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of ...
Le Béchec, Antony, Pawlicki, Sandrine, Delamarche, Christian   +2 more
openaire   +9 more sources

Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [PDF]

Proceedings of the National Academy of Sciences, 2004
Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment.
Thomas C. Südhof, Angela Ho
openaire   +3 more sources

Heteromers of amyloid precursor protein in cerebrospinal fluid [PDF]

Molecular Neurodegeneration, 2015
Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid (CSF) biomarkers for the clinical diagnosis of Alzheimer's disease (AD). However, the capacity of these soluble proteins to assemble has not been explored and could be relevant. Our aim is
Cuchillo-Ibáñez, Inmaculada, López-Font, Inmaculada, Boix-Amorós, Alba, Brinkmalm, Gunnar, Blennow, Kaj, Molinuevo, José Luis, Sáez-Valero, Javier   +6 more
openaire   +7 more sources

Intraneuronal compartments of the amyloid precursor protein [PDF]

The Journal of Neuroscience, 1993
The amyloid precursor protein (APP) is the parent molecule from which beta-amyloid protein is cleaved and deposits as amyloid fibrils in the senile plaques of Alzheimer's disease. Its primary structure resembles a receptor; however, no ligand has been identified. In growing hippocampal neurons APP is localized to growth cones.
Adriana Ferreira, Alfredo Cáceres, Kenneth S. Kosik   +2 more
openaire   +3 more sources

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

PLoS ONE, 2013
Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease.
Nina Stemmer, Elena Strekalova, Nevena Djogo, Frank Plöger, Gabriele Loers, David Lutz, Friedrich Buck, Marek Michalak, Melitta Schachner, Ralf Kleene   +9 more
doaj   +1 more source

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Science, 1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma ...
R. Vassar, B. Bennett, S. Babu-Khan, S. Kahn, E. Mendiaz, P. Denis, D. Teplow, Sandra L. Ross, P. Amarante, R. Loeloff, Yi Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M. Jarosinski, A. Biere, E. Curran, T. Burgess, J. Louis, F. Collins, J. Treanor, Gary Rogers, M. Citron   +23 more
semanticscholar   +1 more source

miR-15b-5p targeting amyloid precursor protein is involved in the anti-amyloid eflect of curcumin in swAPP695-HEK293 cells

Neural Regeneration Research, 2019
Curcumin exerts a neuroprotective effect on Alzheimer’s disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer’s disease cell model. swAPP695-HEK293
Hong-Ying Liu, Xian Fu, You-Fu Li, Xian-Liang Li, Zhen-Yu Ma, Ying Zhang, Qing-Chun Gao   +6 more
doaj   +1 more source