Results 11 to 20 of about 152,781 (323)
Blood, 2021 In this issue of Blood, Konkle et al report that 7 of 8 participants in a phase 1/2 trial of adeno-associated virus (AAV) vector (BAX335) for factor IX (FIX)-Padua gene transfer in patients with hemophilia B did not maintain expression despite steroid intervention, which the authors hypothesize is a result of the innate immune stimulatory effect of ...
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Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Vsevolod J. Makeev +3 more
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Genome Research, 1997 We describe an analysis of the CpG islands (CGIs) of the pig. We have used both database survey and a porcine genomic library that is enriched for CGIs. Approximately half of 41 pig genomic database sequences had CGIs with an average G + C content of 65.3%, an average CpG observed/expected frequency of 0.85, and an average size of 978 bp.
McQueen, H A +4 more
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CpG dinucleotides and the mutation rate of non-CpG DNA [PDF]
Genome Research, 2008 The neutral mutation rate is equal to the base substitution rate when the latter is not affected by natural selection. Differences between these rates may reveal that factors such as natural selection, linkage, or a mutator locus are affecting a given sequence.
Walser, J., Ponger, L., Furano, A. V.
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Current Protocols in Nucleic Acid Chemistry, 2003 AbstractThe vertebrate immune system can recognize specific pathogen‐associated molecular patterns in invading microorganisms, including the unmethylated CpG dinucleotide. This unit discusses the receptors that recognize CpG motifs and important aspects of the sequence context of CpG motifs to the end of understanding and designing CpG DNA for ...
Kandimalla, Ekambar R., Agrawal, Sudhir
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Factors to preserve CpG-rich sequences in methylated CpG islands [PDF]
BMC Genomics, 2015 Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, in our previous study we unexpectedly identified many methylated CGIs in human peripheral blood leukocytes. Methylated CpG dinucleotides convert to TpG dinucleotides through deaminization of their cytosine bases more frequently than ...
Hiroki Miyahara +3 more
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The mutational spectrum of non-CpG DNA varies with CpG content [PDF]
Genome Research, 2010 The accumulation of base substitutions (mutations) not subject to natural selection is the neutral mutation rate. Because this rate reflects the in vivo processes involved in maintaining the integrity of genetic information, the factors that affect the neutral mutation rate are of considerable interest.
Walser, Jean-Claude, Furano, Anthony V.
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CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI [PDF]
Proceedings of the National Academy of Sciences, 2012 Cytosine methylation promotes deamination. In eukaryotes, CpG methylation is thought to account for CpG underrepresentation. Whether scarcity of CpGs in prokaryotic genomes is diagnostic for methylation is not clear. Here, we report that Mycoplasms tend to be CpG depleted and to harbor a family of constitutively expressed or phase variable
Marek Wojciechowski +4 more
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Workflow for Probabilistic Resource Estimation: Jafurah Basin Case Study (Saudi Arabia)
Energies, 2021 This study provides a workflow and preliminary estimations of the estimated ultimate recovery (EUR) volumes for natural gas and condensate liquids in the Tuwaiq Mountain Formation, the principal target in the Jafurah Field development project in Saudi ...
Ruud Weijermars +2 more
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Role of time reversal symmetry and tilting in circular photogalvanic responses [PDF]
Phys. Rev. B 103, 144308 (2021), 2020 We study the role of time reversal symmetry (TRS) in the circular photogalvanic (CPG) responses considering chiral Weyl semimetal (WSM) while a quantized CPG response is guaranteed by broken of both inversion symmetry (IS) and mirror symmetries. The TRS broken WSM yields one left and one right chiral Weyl nodes (WNs) while there are two left and right ...
arxiv +1 more source