Results 11 to 20 of about 389,301 (305)
Journal of Signal Transduction, 2011 The importance of signal transduction cascades such as the EGFR and JAK/STAT pathways for development and homeostasis is highlighted by the high levels of molecular conservation maintained between organisms as evolutionary diverged as fruit flies and humans. This conservation is also mirrored in many of the regulatory mechanisms that control the extent
Stec, W. J., Zeidler, M. P.
openaire +3 more sources
Drosophila Nimrod proteins bind bacteria
Open Life Sciences, 2013 Abstract Engulfment of foreign particles by phagocytes is initiated by the engagement of phagocytic receptors. We have previously reported that NimC1 is involved in the phagocytosis of bacteria in Drosophila melanogaster. We have identified a family of genes, the Nimrod gene superfamily, encoding characteristic NIM domain containing ...
Zsámboki János +7 more
doaj +2 more sources
Drosophila MCM protein complexes. [PDF]
Molecular Biology of the Cell, 1996 MCM genes encode a family of evolutionarily conserved proteins required for DNA replication. In Saccharomyces cerevisiae, where they were first identified, MCM genes interact genetically with each other. Allele specificity in these interactions suggests that MCM proteins physically associate with one another and that this association is essential for ...
T T, Su, G, Feger, P H, O'Farrell
openaire +2 more sources
Distribution of DNA replication proteins in Drosophila cells
BMC Cell Biology, 2007 Background DNA replication in higher eukaryotic cells is organized in discrete subnuclear sites called replication foci (RF). During the S phase, most replication proteins assemble at the RF by interacting with PCNA via a PCNA binding domain (PBD).
Leonhardt Heinrich +2 more
doaj +1 more source
Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]
, 2010 Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core +4 more sources
Searching for Drosophila Dsn1 kinetochore protein [PDF]
Cell Cycle, 2009 The Mis12/MIND kinetochore complex is composed of 4 subunits of which the Dsn1 protein is a crucial component in all organisms where it has been identified. In Caenorhabditis elegans, depletion of Dsn1 results in a so-called "kinetochore null" phenotype, hence Dsn1's alternative name KNL3.
Przewloka, Marcin +2 more
openaire +3 more sources
Frontiers in Oncology, 2013 Drosophila lacks telomerase and fly telomeres are elongated by occasional transposition of three specialized retroelements. Drosophila telomeres do not terminate with GC-rich repeats and are assembled independently of the sequence of chromosome ends ...
Grazia Daniela Raffa +3 more
doaj +1 more source
A novel human polycomb binding site acts as a functional polycomb response element in Drosophila. [PDF]
PLoS ONE, 2012 Polycomb group (PcG) proteins are key chromatin regulators implicated in multiple processes including embryonic development, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ cell differentiation.
Suresh Cuddapah +6 more
doaj +1 more source
Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster.
PLoS ONE, 2007 BackgroundKinetochores are large multiprotein complexes indispensable for proper chromosome segregation. Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochores ...
Marcin R Przewloka +8 more
doaj +1 more source
Fluorescent protein tagging confirms the presence of ribosomal proteins atDrosophilapolytene chromosomes [PDF]
, 2013 \ud \ud Most ribosomal proteins (RPs) are stoichiometrically incorporated into ribosomal subunits and play essential roles in ribosome biogenesis and function.
Bischof +27 more
core +3 more sources