Results 11 to 20 of about 2,797,581 (364)
The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome
Biomolecules, 2023 Nuclear-mitochondrial DNA segments (NUMTs) are mitochondrial DNA (mtDNA) fragments that have been inserted into the nuclear genome. Some NUMTs are common within the human population but most NUMTs are rare and specific to individuals. NUMTs range in size
Liying Xue +3 more
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Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging
Genome Biology, 2020 Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan +12 more
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35 Years of TFAM Research: Old Protein, New Puzzles
Biology, 2023 Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells.
Natalya Kozhukhar, Mikhail F. Alexeyev
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Mitochondrial DNA Methylation and Human Diseases
International Journal of Molecular Sciences, 2021 Epigenetic modifications of the nuclear genome, including DNA methylation, histone modifications and non-coding RNA post-transcriptional regulation, are increasingly being involved in the pathogenesis of several human diseases.
Andrea Stoccoro, F. Coppedè
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Molecules, 2023 Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park +2 more
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Mitochondrial DNA in inflammation and immunity
EMBO Reports, 2020 Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation.
Joel S. Riley, S. Tait
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Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death
Autophagy, 2020 Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li +5 more
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Mitochondrial DNA copy number in human disease: the more the better?
FEBS Letters, 2020 Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense
R. Filograna +3 more
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Genome-wide characterization of mitochondrial DNA methylation in human brain
Frontiers in Endocrinology, 2023 BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction.
Matthew Devall +15 more
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Molecular biology and evolution, 1993 Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as
Kazuko Tamura, M. Nei
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