Results 11 to 20 of about 601,814 (124)
Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis [PDF]
Colloids and Surfaces B: Biointerfaces, Volume 197, January 2021,
111405, 2021 Tuberculosis remains today a major public health issue with a total of 9 million new cases and 2 million deaths annually. The lack of an effective vaccine and the increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics, anticipate a complicated scenario in the near future.
arxiv +1 more source
SplitStrains, a tool to identify and separate mixed Mycobacterium tuberculosis infections from WGS data [PDF]
Microbial Genomics, 7, 2021, 6, 2022 The occurrence of multiple strains of a bacterial pathogen such as M. tuberculosis or C. difficile within a single human host, referred to as a mixed infection, has important implications for both healthcare and public health. However, methods for detecting it, and especially determining the proportion and identities of the underlying strains, from WGS
arxiv +1 more source
Fitting birth-death processes to panel data with applications to bacterial DNA fingerprinting [PDF]
Annals of Applied Statistics 2013, Vol. 7, No. 4, 2315-2335, 2010 Continuous-time linear birth-death-immigration (BDI) processes are frequently used in ecology and epidemiology to model stochastic dynamics of the population of interest. In clinical settings, multiple birth-death processes can describe disease trajectories of individual patients, allowing for estimation of the effects of individual covariates on the ...
arxiv +1 more source
DNA Methylation in hypoxia in Mycobacterium tuberculosis [PDF]
arXiv, 2022 Tuberculosis is one of the most lethal contagious diseases caused by Mycobacterium tuberculosis (MTB), in many cases, the infected did not show any symptoms, because the bacilli entered the dormant stage in granulomas. The dormant stage of MTB is also associated with higher resistance to drugs and the immune system.
arxiv
mBio, 2017 The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance (RIF-R) suitable for point-of-care testing. However, it has decreased sensitivity in smear-negative sputum, and false identification of RIF-R occasionally ...
S. Chakravorty +24 more
semanticscholar +1 more source
Prediction of Tuberculosis using U-Net and segmentation techniques [PDF]
arXiv, 2021 One of the most serious public health problems in Peru and worldwide is Tuberculosis (TB), which is produced by a bacterium known as Mycobacterium tuberculosis. The purpose of this work is to facilitate and automate the diagnosis of tuberculosis using the MODS method and using lens-free microscopy, as it is easier to calibrate and easier to use by ...
arxiv
IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
Nature Network Boston, 2019 Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI).
Lenette L. Lu +20 more
semanticscholar +1 more source
The molecular clock of Mycobacterium tuberculosis
bioRxiv, 2019 The molecular clock and its phylogenetic applications to genomic data have changed how we study and understand one of the major human pathogens, Mycobacterium tuberculosis (MTB), the causal agent of tuberculosis.
Fabrizio Menardo +3 more
semanticscholar +1 more source
Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease [PDF]
, 2017 Tuberculosis relapse is a barrier to shorter treatment. It is thought that lipid rich cells, phenotypically resistant to antibiotics, may play a major role. Most studies investigating relapse use sputum samples although tissue bacteria may play an important role. We developed a non-destructive, label-free technique combining wavelength modulated Raman (
arxiv +1 more source
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen
FEMS Microbiology Reviews, 2019 Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal of effective antimicrobials, targeting novel ...
Arundhati Maitra +6 more
semanticscholar +1 more source