Results 11 to 20 of about 114 (67)

Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation

open access: yesCHIMIA, 2013
Recent progress in the synthesis, screening, and self-assembly of nucleic acid–tagged peptidic libraries is reviewed.
Kalyan K. Sadhu, Nicolas Winssinger
doaj   +1 more source

Quantification bias caused by plasmid DNA conformation in quantitative real-time PCR assay. [PDF]

open access: yesPLoS ONE, 2011
Quantitative real-time PCR (qPCR) is the gold standard for the quantification of specific nucleic acid sequences. However, a serious concern has been revealed in a recent report: supercoiled plasmid standards cause significant over-estimation in qPCR ...
Chih-Hui Lin   +2 more
doaj   +1 more source

Protein-DNA interactions: statistical analysis of interatomic contacts in major and minor grooves

open access: yesВавиловский журнал генетики и селекции, 2018
The interactions between protein and DNA in essence underlie all processes in a living cell. Understanding the principles of specific recognition of DNA sites will open the way to understand how these processes are controlled and to interfere in their ...
A. A. Anashkina   +5 more
doaj   +1 more source

Solution conformation of 2-aminopurine dinucleotide determined by ultraviolet two-dimensional fluorescence spectroscopy

open access: yesNew Journal of Physics, 2013
We have observed the conformation-dependent electronic coupling between the monomeric subunits of a dinucleotide of 2-aminopurine (2-AP), a fluorescent analogue of the nucleic acid base adenine.
Julia R Widom   +3 more
doaj   +1 more source

Insights on the DNA Stability in Aqueous Solutions of Ionic Liquids

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Deoxyribonucleic acid (DNA) carries the genetic information essential for the growth and functioning of living organisms, playing a significant role in life sciences research.
Teresa B. V. Dinis   +2 more
doaj   +1 more source

Microgels and apparatus for PAGE of nucleic acids in one or two dimensions

open access: yesBioTechniques, 2018
We describe a system for horizontal 1D or 2D PAGE comprising an apparatus and microgels. There is no buffer outside the gel, making handling and sample loading easy.
Hans G Thormar   +5 more
doaj   +1 more source

T7 RNA polymerase functions in vitro without clustering. [PDF]

open access: yesPLoS ONE, 2012
Many nucleic acid polymerases function in clusters known as factories. We investigate whether the RNA polymerase (RNAP) of phage T7 also clusters when active.
Kieran Finan   +3 more
doaj   +1 more source

IFITs: Emerging Roles As Key Anti-Viral Proteins

open access: yesFrontiers in Immunology, 2014
Interferon-induced protein with tetratricopeptide repeats (IFITs) are a family of proteins which are strongly induced downstream of type I interferon (IFN) signaling.
Gregory I Vladimer   +2 more
doaj   +1 more source

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

open access: yesCrystals, 2022
Heteroduplexes composed of all-DNA and all-2′-OMe RNA strands do not occur in nature, but they have found application in the development of molecular beacons and could also be used as aptamers or elements of nucleic acid-based nanostructures that will ...
Rafał Dolot   +3 more
doaj   +1 more source

Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions

open access: yesJournal of Nucleic Acids, 2011
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano   +2 more
doaj   +1 more source

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