Results 11 to 20 of about 38,575 (293)

Prediction of proprotein convertase cleavage sites [PDF]

Protein Engineering, Design and Selection, 2004
Many secretory proteins and peptides are synthesized as inactive precursors that in addition to signal peptide cleavage undergo post-translational processing to become biologically active polypeptides. Precursors are usually cleaved at sites composed of single or paired basic amino acid residues by members of the subtilisin/kexin-like proprotein ...
Peter Duckert, Nikolaj Blom, Søren Brunak   +2 more
openaire   +4 more sources

Assessment of serum proprotein convertase subtilisin/kexin type 9 in pediatric sepsis syndrome [PDF]

Scientific Reports
Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme released in response to the drop in cholesterol level ...
Suzan Omar Mousa, Mohamed Farouk Afifi, Noha Anwar Hassuna, Michael Fekry Yassa, Hend Mohamed Moness   +4 more
doaj   +2 more sources

The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response

Frontiers in Immunology, 2021
Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of cellular pro-proteins. They trigger the activation, inactivation or functional changes of many hormones, neuropeptides, growth factors and receptors.
Mélanie Rose, Marie Duhamel, Franck Rodet   +2 more
exaly   +3 more sources

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations [PDF]

Frontiers in Pharmacology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu, En Li, Xiaoyu Yang, Xiaoyu Yang   +3 more
doaj   +2 more sources

From lipoprotein apheresis to proprotein convertase subtilisin/kexin type 9 inhibitors: Impact on low-density lipoprotein cholesterol and C-reactive protein levels in cardiovascular disease patients

European Journal of Preventive Cardiology, 2018
In this observational study, we compared the effect of lipoprotein apheresis and evolocumab or alirocumab on levels of lipoprotein cholesterol, triglycerides and inflammatory markers (C reactive protein and interleukin 6) in cardiovascular patients (n ...
Maria Giovanna Lupo, Alberto Corsini, Massimiliano Ruscica   +2 more
exaly   +2 more sources

Enteroendocrine Dysfunction in Two Saudi Sisters

Case Reports in Gastroenterology, 2021
Proprotein convertase (PC) deficiency is a rare autosomal recessive disorder caused by mutations in proprotein convertase subtilisin/kexin type 1 (PCSK1).
Amna Basheer M. Ahmed, Badr M. Rasheed Alsaleem   +1 more
doaj   +1 more source

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms

Circulation Research, 2022
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density lipoprotein (LDL)
Shunsuke Katsuki, Prabhash Kumar Jha, A. Lupieri, T. Nakano, Livia S A Passos, M. Rogers, Dakota R. Becker-Greene, Thanh-Dat Le, J. Decano, Lang Ho Lee, G. C. Guimarães, Ilyes Abdelhamid, A. Halu, A. Muscoloni, Carlo Vittorio Cannistraci, Hideyuki Higashi, Hengmin Zhang, Amélie Vromman, P. Libby, C. Keith Ozaki, Amitabh Sharma, Sasha A. Singh, E. Aikawa, M. Aikawa   +23 more
semanticscholar   +1 more source

Injection of an improperly stored proprotein convertase subtilisin/kexin type 9 monoclonal antibody in a patient with secondary dyslipidemia from nephrotic syndrome: a case report

Journal of Medical Case Reports, 2023
Background Elevated plasma cholesterol and/or plasma triglyceride levels in nephrotic syndrome patients are the result of impaired lipoprotein clearance and a compensatory increase in hepatic lipoprotein synthesis. Plasma proprotein convertase subtilisin/
Tanawan Kongmalai, Nalinee Chuanchaiyakul, Yuttana Srinoulprasert, Nuntakorn Thongtang   +3 more
doaj   +1 more source

Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond

International Journal of Molecular Sciences, 2022
Chronic liver diseases are commonly associated with dysregulated cholesterol metabolism. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease of the proprotein convertase family that is mainly synthetized and secreted by the liver ...
T. Grewal, C. Buechler
semanticscholar   +1 more source

Proprotein Convertases and the Complement System

Frontiers in Immunology, 2022
Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs). Prohormones are typically processed in the regulated secretory pathway, while most plasma proteins travel though the constitutive pathway.
József Dobó, Andrea Kocsis, Ráhel Dani, Péter Gál   +3 more
openaire   +3 more sources