Results 11 to 20 of about 56,983 (273)

Evaluation of sweating responses in patients with systemic connective tissue disorders using the quantitative sudomotor axon reflex test

Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 208-216, December 2022., 2022
We investigated 85 patients on the relationship between the axon reflex sweat volume or the reaction time and Raynaud's phenomenon, skin symptoms and patient background. Most patients did not show a decrease in sweating, but one in three patients showed less sweating in summer than in winter.
Miwa Ashida, Shimpei Morimoto, Mariko Yozaki, Daisuke Ehara, Yuta Koike, Hiroyuki Murota   +5 more
wiley   +1 more source

Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis

Arthritis Research & Therapy, 2021
Background Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease duration, severity, clinical ...
David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai, Dinesh Khanna   +14 more
doaj   +1 more source

Scleroderma

Definitions, 2020
To the Editor: In their review article on scleroderma, Gabrielli et al. (May 7 issue)1 incorporate their earlier observations that all patients with this disease have activating antibodies to platelet-derived growth factor (PDGF) receptors (PDGFRs).2 ...
E. Lawson
semanticscholar   +1 more source

Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America

JGH Open, Volume 6, Issue 12, Page 904-909, December 2022., 2022
Classically described in the group of non‐cirrhotic portal hypertension, obliterative portal venopathy (OPV) causes are still unknown. Our aim is to describe the characteristics of 43 OPV patients and potential risk factors. Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was elevation
Vinícius Nunes, Luiz A R de Freitas, Juliana R de Freitas, Caio Araújo, Gildásio N Junior, Maria I Schinoni, Fernando Bessone, Raymundo Paraná   +7 more
wiley   +1 more source

Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes

Scientific Reports, 2021
Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano, Heidi Hermes, Sonsoles Piera-Velazquez, Sankar Addya, Francesco Del Galdo, Sergio A. Jimenez   +5 more
doaj   +1 more source

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Nature Communications, 2022
A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by
Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga   +23 more
doaj   +1 more source

Mapping the complex everyday challenges and needs of people with rheumatic disease and their surroundings using a multi‐actor approach

Musculoskeletal Care, Volume 20, Issue 4, Page 873-891, December 2022., 2022
Abstract Introduction This study aimed to gain insight into the real‐world complexity of the challenges experienced by patients, their significant others, care professionals and the work and education environment concerning rheumatic diseases as well as the interrelation between these challenges; it also aimed to prioritise the identified challenges ...
Simone Harmsen, Joyce A. Nabuurs, Lotte F. Lehman de Lehnsfeld, Marjoleine G. van der Meij, Jacqueline E. W. Broerse, Carina A. C. M. Pittens   +5 more
wiley   +1 more source

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

Frontiers in Immunology, 2018
Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc ...
Swati Bhattacharyya, Wenxia Wang, Zenshiro Tamaki, Bo Shi, Anjana Yeldandi, Yasuhiro Tsukimi, Masashi Yamasaki, John Varga   +7 more
doaj   +1 more source

Myeloablative Autologous Stem‐Cell Transplantation for Severe Scleroderma

New England Journal of Medicine, 2018
BACKGROUND Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem‐cell transplantation with immunosuppression by means of 12 ...
K. Sullivan, E. Goldmuntz, L. Keyes‐Elstein, P. Mcsweeney, A. Pinckney, B. Welch, M. Mayes, R. Nash, L. Crofford, Barry E Eggleston, Sharon M Castina, Linda M. Griffith, J. Goldstein, Dennis Wallace, O. Craciunescu, D. Khanna, R. Folz, J. Goldin, W. St Clair, J. Seibold, K. Phillips, S. Mineishi, R. Simms, K. Ballen, M. Wener, G. Georges, S. Heimfeld, C. Hosing, S. Forman, S. Kafaja, R. Silver, Leroy. W. Griffing, J. Storek, S. Leclercq, R. Brasington, M. Csuka, C. Bredeson, C. Keever-Taylor, R. Domsic, B. Kahaleh, T. Medsger, D. Furst   +41 more
semanticscholar   +1 more source

UEG and EAES rapid guideline: Update systematic review, network meta‐analysis, CINeMA and GRADE assessment, and evidence‐informed European recommendations on surgical management of GERD

United European Gastroenterology Journal, Volume 10, Issue 9, Page 983-998, November 2022., 2022
Abstract Background There are several options for the surgical management of GERD in adults. Previous guidelines and systematic reviews have compared the effects of total fundoplication versus pooled effects of different techniques of partial fundoplication.
Sheraz Markar, Alexandros Andreou, Luigi Bonavina, Ivan D. Florez, Bright Huo, Katerina‐Maria Kontouli, Donald E. Low, Dimitris Mavridis, Nick Maynard, Alan Moss, Manuel Pera, Edoardo Savarino, Peter Siersema, Daniel Sifrim, David I. Watson, Giovanni Zaninotto, Stavros A. Antoniou   +16 more
wiley   +1 more source