Results 11 to 20 of about 189,215 (267)

Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability

Pathogens, 2021
Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity even if treated.
Julie Huynh, Yara-Natalie Abo, Karen du Preez, Regan Solomons, Kelly E Dooley, James A Seddon   +5 more
doaj   +2 more sources

A Rare Clinical Manifestation of Disseminated Tuberculosis: Case Report of Tuberculous Meningitis With Flaccid Paralysis. [PDF]

Clin Case Rep
ABSTRACT This case highlights a rare presentation of disseminated tuberculosis in a child, manifesting as tuberculous meningitis and flaccid paralysis due to spinal tuberculosis. Timely initiation of antitubercular therapy, corticosteroids, and ventriculoperitoneal shunt placement led to full recovery, emphasizing tuberculosis consideration in atypical
Haleem A, Ashraf S, Ahsan A, Qadri M, Shahid I, Ayalew BD.   +5 more
europepmc   +2 more sources

Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

New England Journal of Medicine, 2023
Background Adjunctive corticosteroids are widely used to treat HIV-associated tuberculous meningitis despite limited data supporting their safety and efficacy. Methods We conducted a randomized double-blind placebo-controlled trial in HIV-positive adults
Joseph Donovan, N. D. Bang, Darma Imran, Ho D T Nghia, Erlina Burhan, Dau T T Huong, Nguyen T T Hiep, L. H. Ngoc, D. V. Thanh, Nguyen T Thanh, Anna L S Wardhani, Kartika Maharani, C. P. Gasmara, Nguyen H H Hanh, P. Oanh, R. Estiasari, Do D A Thu, Ardiana Kusumaningrum, Le T Dung, D. C. Giang, Dang T M Ha, N. H. Lân, Nguyen V V Chau, N. T. M. Nguyet, R. Geskus, Nguyen T T Thuong, E. Kestelyn, R. Hamers, N. Phu, Guy E. Thwaites   +29 more
semanticscholar   +1 more source

The global burden of tuberculous meningitis in adults: A modelling study

PLOS Global Public Health, 2021
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and mortality of TBM is unknown due to diagnostic challenges and limited disaggregated reporting of treated TBM by existing surveillance systems. We aimed to estimate the
P. Dodd, M. Osman, F. Cresswell, Anna M. Stadelman, N. H. Lân, N. Thuong, M. Muzyamba, Lisa Glaser, S. Dlamini, J. Seddon   +9 more
semanticscholar   +1 more source

Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis

Microbiology spectrum, 2022
As the most severe form of tuberculosis, the pathogenesis of tuberculous meningitis (TBM) is still unclear. Gut microbiota dysbiosis plays an important role in a variety of central nervous system diseases.
Shanshan Li, Jidong Guo, Rongmei Liu, Fuzhen Zhang, Shu’an Wen, Yi Liu, Weicong Ren, Xu-xia Zhang, Y. Shang, M. Gao, Jie Lu, Y. Pang   +11 more
semanticscholar   +1 more source

High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis

Journal of Clinical Investigation, 2022
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality.
Camilo A. Ruiz-Bedoya, F. Mota, E. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, Melissa Bahr, Kelly Flavahan, Patricia de Jesus, John Kim, C. Foss, C. Peloquin, D. Hammoud, A. Ordonez, C. Pardo, Sanjay K. Jain   +15 more
semanticscholar   +1 more source

Improving Technology to Diagnose Tuberculous Meningitis: Are We There Yet?

Frontiers in Neurology, 2022
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance diagnostics. Even those that have reasonable sensitivity are not adequate to ‘rule out' TBM.
K. Ssebambulidde, J. Gakuru, J. Ellis, F. Cresswell, N. Bahr   +4 more
semanticscholar   +1 more source

Global Frequency and Clinical Features of Stroke in Patients With Tuberculous Meningitis

JAMA Network Open, 2022
Key Points Question What is the global frequency of stroke in patients with tuberculous meningitis (TBM)? Findings In this systematic review including 852 articles involving 2194 patients with stroke in TBM, the estimated frequency of stroke in TBM was 0.
M. C. Sy, A. Espiritu, J. L. R. Pascual
semanticscholar   +1 more source

Cognitive Impairment in Tuberculous Meningitis

Clinical Infectious Diseases, 2022
Background Cognitive impairment is reported as a common complication in adult tuberculous meningitis (TBM), yet few studies have systematically assessed the frequency and nature of impairment.
A. Davis, Anna J. Dreyer, C. Albertyn, M. Maxebengula, C. Stek, S. Wasserman, S. Marais, K. Bateman, M. Solms, J. Joska, R. Wilkinson, S. Nightingale   +11 more
semanticscholar   +1 more source

Plasma Pharmacokinetics of High-Dose Oral versus Intravenous Rifampicin in Patients with Tuberculous Meningitis: a Randomized Controlled Trial

medRxiv, 2021
Higher doses of intravenous rifampicin may improve outcomes in tuberculous meningitis but are impractical in high-burden settings. We hypothesized that plasma rifampicin exposures would be similar between oral dosing of 35 mg/kg of body weight and ...
S. Wasserman, A. Davis, C. Stek, M. Chirehwa, S. Botha, R. Daroowala, Marise Bremer, M. Maxebengula, Sonya Koekemoer, R. Goliath, A. Jackson, T. Crede, J. Naudé, P. Szymanski, Y. Vallie, M. S. Moosa, L. Wiesner, J. Black, G. Meintjes, G. Maartens, R. Wilkinson   +20 more
semanticscholar   +1 more source