Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations [PDF]
eLife, 2023 Transfer RNAs (tRNAs) in bacteriophage genomes are widespread across bacterial host genera, but their exact function has remained unclear for more than 50 years.
Daan F van den Berg +3 more
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PLoS ONE, 2014 The prokaryotic ubiquitous Toxin-Antitoxin (TA) operons encode a stable toxin and an unstable antitoxin. The most accepted hypothesis of the physiological function of the TA system is the reversible cessation of cellular growth under stress conditions ...
Alexandre P Y Lopes +8 more
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The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability [PDF]
MicroorganismsBacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano +6 more
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Focused Overview of Mycobacterium tuberculosis VapBC Toxin–Antitoxin Systems Regarding Their Structural and Functional Aspects: Including Insights on Biomimetic Peptides [PDF]
Biomimetics, 2023 Tuberculosis, caused by Mycobacterium tuberculosis, is a lethal infectious disease of significant public health concern. The rise of multidrug-resistant and drug-tolerant strains has necessitated novel approaches to combat the disease.
Sung-Min Kang
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system [PDF]
mBioToxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division.
Sarah Hollingshead +10 more
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PLoS ONE, 2012 Nearly 200 million people are infected by hepatitis C virus (HCV) worldwide. For replicating the HCV genome, the membrane-associated machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB ...
Shaveta Goyal +6 more
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Toxins VapC and PasB from Prokaryotic TA Modules Remain Active in Mammalian Cancer Cells
Toxins, 2014 Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine.
Łukasz Wieteska +3 more
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Apoptosis like symptoms associated with abortive infection of Mycobacterium smegmatis by mycobacteriophage D29. [PDF]
PLoS ONE, 2022 Mycobacteriophages are phages that infect mycobacteria resulting in their killing. Although lysis is the primary mechanism by which mycobacteriophages cause cell death, others such as abortive infection may also be involved.
Fatema Calcuttawala +5 more
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Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria [PDF]
Malaria Journal, 2023 Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control.
Alima Qureshi, John B. Connolly
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Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [PDF]
Infection and ImmunityChlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner +3 more
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