Results 1 to 10 of about 535 (100)

Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system [PDF]

mBio
Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division.
Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang   +10 more
doaj   +4 more sources

Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]

Communications Biology
The VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh, Gopinath Chattopadhyay, Niranjana Sri Sundaramoorthy, Raghavan Varadarajan, Ramandeep Singh   +4 more
doaj   +3 more sources

Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis [PDF]

Communications Biology
The expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26 TA modules of M. tuberculosis.
Arun Sharma, Neelam Singh, Munmun Bhasin, Prabhakar Tiwari, Pankaj Chopra, Raghavan Varadarajan, Ramandeep Singh   +6 more
doaj   +3 more sources

The Benefits of Toxicity: M. smegmatis VapBC TA Module Is Induced by Tetracycline Exposure and Promotes Survival [PDF]

Microorganisms, 2023
Toxin–antitoxin (TA) systems are widely present in bacterial genomes. Mycolicibacterium smegmatis, a common model organism for studying Mycobacterium tuberculosis physiology, has eight TA loci, including mazEF and vapBC.
Mikhail Zamakhaev, Julia Bespyatykh, Anna Goncharenko, Mikhail Shumkov   +3 more
doaj   +2 more sources

Impact of Genomic Deletion RD16 on the Expression of the Mycobacterium bovis BCG Moreau VapBC47 Toxin-Antitoxin System [PDF]

Current Issues in Molecular Biology, 2023
Mycobacterium bovis BCG is the only vaccine against tuberculosis. The variable forms of cultivation throughout the years, before seed-lots were developed, allowed in vitro evolution of the original strain, generating a family of vaccines with different ...
Talita Duarte Pagani, Paloma Rezende Corrêa, Cristiane Lima, Leonardo Henrique Ferreira Gomes, Marcos Gustavo Araujo Schwarz, Teca Calcagno Galvão, Wim Maurits Degrave, Napoleão Fonseca Valadares, Leila Mendonça-Lima   +8 more
doaj   +2 more sources

Mycobacterium tuberculosis Rv0229c Shows Ribonuclease Activity and Reveals Its Corresponding Role as Toxin VapC51 [PDF]

Antibiotics, 2023
The VapBC system, which belongs to the type II toxin–antitoxin (TA) system, is the most abundant and widely studied system in Mycobacterium tuberculosis.
Sung-Min Kang
doaj   +2 more sources

Focused Overview of Mycobacterium tuberculosis VapBC Toxin–Antitoxin Systems Regarding Their Structural and Functional Aspects: Including Insights on Biomimetic Peptides [PDF]

Biomimetics, 2023
Tuberculosis, caused by Mycobacterium tuberculosis, is a lethal infectious disease of significant public health concern. The rise of multidrug-resistant and drug-tolerant strains has necessitated novel approaches to combat the disease.
Sung-Min Kang
doaj   +2 more sources

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation [PDF]

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +2 more sources

VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host. [PDF]

PLoS Pathogens
Toxin-antitoxin (TA) modules enable bacteria to persist under stressful environments. However, they are typically absent from host-associated prokaryotes due to their potential host toxicity. Here, the obligate intracellular bacterium spotted fever group
Yan Liu, Weiting Zhou, Jiaying Zhao, Qingyin Shi, Yu Xin, Xuan Ouyang, Yonghui Yu, Jun Jiao, Maozhang He, Yajun Song, Kehan Xu   +10 more
doaj   +2 more sources

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability [PDF]

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +2 more sources