Shared Mechanisms of Enhanced Plasmid Maintenance and Antibiotic Tolerance Mediated by the VapBC Toxin:Antitoxin System. [PDF]
MBioToxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division.
Christoph M Tang +2 more
exaly +8 more sources
A Haloarchaeal VapBC Toxin-Antitoxin System: Regulatory Mechanism and Role in Establishing Population Heterogeneity to Facilitate Survival of Subpopulations Under Stress Conditions. [PDF]
Applied and Environmental MicrobiologyToxin-antitoxin (TA) systems are ubiquitously distributed in bacteria and archaea and have been implicated in various functions such as plasmid maintenance, phage defense, biofilm formation, stress response, and persistence, but their regulatory ...
Fei Gan, Xiao-Feng Tang, Bing Tang
exaly +6 more sources
The Benefits of Toxicity: M. smegmatis VapBC TA Module Is Induced by Tetracycline Exposure and Promotes Survival [PDF]
Microorganisms, 2023 Toxin–antitoxin (TA) systems are widely present in bacterial genomes. Mycolicibacterium smegmatis, a common model organism for studying Mycobacterium tuberculosis physiology, has eight TA loci, including mazEF and vapBC.
Mikhail Zamakhaev +3 more
doaj +5 more sources
The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation [PDF]
MicroorganismsToxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo +5 more
doaj +5 more sources
Focused Overview of Mycobacterium tuberculosis VapBC Toxin–Antitoxin Systems Regarding Their Structural and Functional Aspects: Including Insights on Biomimetic Peptides [PDF]
Biomimetics, 2023 Tuberculosis, caused by Mycobacterium tuberculosis, is a lethal infectious disease of significant public health concern. The rise of multidrug-resistant and drug-tolerant strains has necessitated novel approaches to combat the disease.
Sung-Min Kang
doaj +5 more sources
The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability [PDF]
MicroorganismsBacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano +6 more
doaj +5 more sources
International Journal of Mycobacteriology, 2020 Background: Mycobacterium smegmatis and other nontuberculous mycobacteria (NTM) are widely distributed in the environment, but a significant increase of NTM infections has taken place in the last few decades.
Daria V Eroshenko +2 more
doaj +4 more sources
Interplay between transcriptional regulators and VapBC toxin-antitoxin loci during thermal stress response in extremely thermoacidophilic archaea. [PDF]
Environ Microbiol, 2023 Summary Thermoacidophilic archaea lack sigma factors and the large inventory of heat shock proteins (HSP) widespread in bacterial genomes, suggesting other strategies for handling thermal stress are involved.
Cooper CR +6 more
europepmc +4 more sources
Impact of Genomic Deletion RD16 on the Expression of the Mycobacterium bovis BCG Moreau VapBC47 Toxin-Antitoxin System [PDF]
Current Issues in Molecular Biology, 2023 Mycobacterium bovis BCG is the only vaccine against tuberculosis. The variable forms of cultivation throughout the years, before seed-lots were developed, allowed in vitro evolution of the original strain, generating a family of vaccines with different ...
Talita Duarte Pagani +8 more
doaj +2 more sources
Mycobacterium tuberculosis Rv0229c Shows Ribonuclease Activity and Reveals Its Corresponding Role as Toxin VapC51 [PDF]
Antibiotics, 2023 The VapBC system, which belongs to the type II toxin–antitoxin (TA) system, is the most abundant and widely studied system in Mycobacterium tuberculosis.
Sung-Min Kang
doaj +2 more sources