Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens. [PDF]
RNA, 2021 Toxin–antitoxin (TA) systems are genetic modules composed of a toxin interfering with cellular processes and its cognate antitoxin, which counteracts the activity of the toxin. TA modules are widespread in bacterial and archaeal genomes. It has been suggested that TA modules participate in the adaptation of prokaryotes to unfavorable conditions.
Jeon H, Choi E, Hwang J.
europepmc +4 more sources
Microorganisms, 2021 The structure-function relationships of toxin-antitoxin (TA) systems from Mycobacterium tuberculosis have prompted the development of novel and effective antimicrobial agents that selectively target this organism.
Sung-Min Kang +6 more
doaj +1 more source
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. [PDF]
PLoS ONE, 2014 Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells.
Brooke Hamilton +4 more
doaj +1 more source
Toxin-antitoxinvapBClocus participates in formation of the dormant state inMycobacterium smegmatis [PDF]
FEMS Microbiology Letters, 2014 Toxin-antitoxin (TA) loci are widely spread in bacterial plasmids and chromosomes. Toxins affect important functions of bacterial cells such as translation, replication and cell-wall synthesis, whereas antitoxins are toxin inhibitors. Participation in formation of the dormant state in bacteria is suggested to be a possible function of toxins.
Oksana I, Demidenok +2 more
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Preliminary crystallographic analysis of recombinant VapBC-15 toxin–antitoxin complex fromMycobacterium tuberculosis [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013 The Mycobacterium tuberculosis vapBC15 locus encodes a toxin-antitoxin complex. VapC-15 is a toxin and possesses ribonuclease activity and VapB-15 is an antitoxin which both binds and inhibits the VapC-15 toxin. In this study, vapBC15 genes were cloned and co-expressed in Escherichia coli.
Uddipan, Das +3 more
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Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. [PDF]
PLoS ONE, 2015 Bacterial persister cells are considered a basis for chronic infections and relapse caused by bacterial pathogens. Persisters are phenotypic variants characterized by low metabolic activity and slow or no replication.
Eugenia Silva-Herzog +3 more
doaj +1 more source
Integrated mobile genetic elements in Thaumarchaeota
Environmental Microbiology, Volume 21, Issue 6, Page 2056-2078, June 2019., 2019 Summary To explore the diversity of mobile genetic elements (MGE) associated with archaea of the phylum Thaumarchaeota, we exploited the property of most MGE to integrate into the genomes of their hosts. Integrated MGE (iMGE) were identified in 20 thaumarchaeal genomes amounting to 2 Mbp of mobile thaumarchaeal DNA.
Mart Krupovic +6 more
wiley +1 more source
When Ribonucleases Come into Play in Pathogens: A Survey of Gram‐Positive Bacteria
International Journal of Microbiology, Volume 2012, Issue 1, 2012., 2012 It is widely acknowledged that RNA stability plays critical roles in bacterial adaptation and survival in different environments like those encountered when bacteria infect a host. Bacterial ribonucleases acting alone or in concert with regulatory RNAs or RNA binding proteins are the mediators of the regulatory outcome on RNA stability.
Brian C. Jester +3 more
wiley +1 more source
VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity. [PDF]
PLoS ONE, 2018 The chromosome of Mycobacterium tuberculosis (Mtb) contains a large number of Type II toxin-antitoxin (TA) systems. The majority of these belong to the VapBC TA family, characterised by the VapC protein consisting of a PIN domain with four conserved ...
Abigail Sharrock +4 more
doaj +1 more source
Recent Advancements in Toxin and Antitoxin Systems Involved in Bacterial Programmed Cell Death
International Journal of Microbiology, Volume 2010, Issue 1, 2010., 2010 Programmed cell death (PCD) systems have been extensively studied for their significant role in a variety of biological processes in eukaryotic organisms. Recently, more and more researches have revealed the existence of similar systems employed by bacteria in response to various environmental stresses.
Ming-xi Hu +4 more
wiley +1 more source