Results 41 to 50 of about 724 (156)
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Chronic infections and treatment failure are concerning issues in patients with Pseudomonas aeruginosa infections. Persister cell formation in biofilm is considered a key reason for antibiotic resistance and treatment failure.
Rezvan Golmoradi Zadeh +5 more
doaj +1 more source
Microorganisms, 2021 The structure-function relationships of toxin-antitoxin (TA) systems from Mycobacterium tuberculosis have prompted the development of novel and effective antimicrobial agents that selectively target this organism.
Sung-Min Kang +6 more
doaj +1 more source
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. [PDF]
PLoS ONE, 2014 Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells.
Brooke Hamilton +4 more
doaj +1 more source
Toxin-antitoxinvapBClocus participates in formation of the dormant state inMycobacterium smegmatis [PDF]
FEMS Microbiology Letters, 2014 Toxin-antitoxin (TA) loci are widely spread in bacterial plasmids and chromosomes. Toxins affect important functions of bacterial cells such as translation, replication and cell-wall synthesis, whereas antitoxins are toxin inhibitors. Participation in formation of the dormant state in bacteria is suggested to be a possible function of toxins.
Oksana I, Demidenok +2 more
openaire +2 more sources
VapBC systems characterised in this study. [PDF]
, 2018 Conserved domains and homologous VapB proteins were identified by homology searches using pBLAST. Predicted molecular weights (MWs) of VapBC heterodimers were calculated by ProtParam [28].
Joanna L. Hicks (5706827) +4 more
core +1 more source
Expression from the NTHi vapBC-1 promoter. [PDF]
, 2013 β-galactosidase activity indicating lacZ expression under vapBC-1 promoter control in wild type R2866 (diamonds), and R2866 mutants, Δfis (squares), ΔvapBC-1 (crosses), and Δfis ΔvapBC-1 (triangles), was measured every 30 minutes for 2 hours after ...
Sehresh Saleem (329519) +2 more
core +1 more source
Preliminary crystallographic analysis of recombinant VapBC-15 toxin–antitoxin complex fromMycobacterium tuberculosis [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013 The Mycobacterium tuberculosis vapBC15 locus encodes a toxin-antitoxin complex. VapC-15 is a toxin and possesses ribonuclease activity and VapB-15 is an antitoxin which both binds and inhibits the VapC-15 toxin. In this study, vapBC15 genes were cloned and co-expressed in Escherichia coli.
Uddipan, Das +3 more
openaire +2 more sources
Model for the regulation of the vapBC-1 locus. [PDF]
, 2013 (A) During colonization under favourable conditions, the VapBC-1 complex binds to and autorepresses TA operon transcription. (B) Stress induces Lon and Clp proteases that degrade VapB-1, releasing active VapC-1 toxin.
Sehresh Saleem (329519) +2 more
core +1 more source
Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. [PDF]
PLoS ONE, 2015 Bacterial persister cells are considered a basis for chronic infections and relapse caused by bacterial pathogens. Persisters are phenotypic variants characterized by low metabolic activity and slow or no replication.
Eugenia Silva-Herzog +3 more
doaj +1 more source
Integrated mobile genetic elements in Thaumarchaeota
Environmental Microbiology, Volume 21, Issue 6, Page 2056-2078, June 2019., 2019 Summary To explore the diversity of mobile genetic elements (MGE) associated with archaea of the phylum Thaumarchaeota, we exploited the property of most MGE to integrate into the genomes of their hosts. Integrated MGE (iMGE) were identified in 20 thaumarchaeal genomes amounting to 2 Mbp of mobile thaumarchaeal DNA.
Mart Krupovic +6 more
wiley +1 more source