Results 61 to 70 of about 721 (155)
The ntrPR Operon of Sinorhizobium meliloti Is Organized and Functions as a Toxin-Antitoxin Module
Molecular Plant-Microbe Interactions, 2006 The chromosomal ntrPR operon of Sinorhizobium meliloti encodes a protein pair that forms a toxin-antitoxin (TA) module, the first characterized functional TA system in Rhizobiaceae. Similarly to other bacterial TA systems, the toxin gene ntrR is preceded
Monica Bodogai +5 more
doaj +1 more source
The Journal of biological chemistry, 2009 In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis.
Linda, Miallau +6 more
openaire +1 more source
PLoS ONE, 2013 Mobilome of hyperthermophilic archaea dwelling in deep-sea hydrothermal vents is poorly characterized. To gain insight into genetic diversity and dynamics of mobile genetic elements in these environments we have sequenced five new plasmids from different
Mart Krupovic +4 more
doaj +1 more source
The crystal structure of the Rv0301‐Rv0300 VapBC‐3 toxin—antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA‐binding site [PDF]
Protein Science, 2012 AbstractVapBC pairs account for 45 out of 88 identified toxin‐antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the metabolism of the cell, which in the case of VapC toxins is via their RNase activity.
Andrew B. Min +5 more
openaire +1 more source
Toxins, 2016 Toxin-antitoxin (TA) systems are small genetic elements that are ubiquitous in prokaryotes. Most studies on TA systems have focused on commensal and pathogenic bacteria; yet very few studies have focused on TAs in marine bacteria, especially those ...
Yunxue Guo +4 more
doaj +1 more source
VapBC-1 specifically interacts with the vapB-1 TIR.
, 2013 (A) The sequence of the 50TIR is shown with arrows indicating the inverted repeat regions and bases above and below the sequence indicating the position of the G to C and T to G substitutions in the TG50TIR and 2M50TIR substrates (see Table 3). Gel shift
Sehresh Saleem (329519) +2 more
core +1 more source
Frontiers in Microbiology, 2015 -Objectives:Previously 14 conjugative plasmids from multi-drug resistant (MDR) Escherichia coli from healthy humans and food-producing animals in Switzerland were sequenced.
JUAN eWANG +5 more
doaj +1 more source
Fis, VapC-1 and VapBC-1 bind the vapB-1 TIR.
, 2013 (A) The sequence of the 50TIR indicating the putative Fis binding site (underline) and the inverted repeat regions (arrows). (B) Gel shift products from samples containing 50TIR alone (lane 1) and 10, 30, 150 or 600 molar ratios of Fis to DNA.
Sehresh Saleem (329519) +2 more
core +1 more source
Frontiers in Microbiology, 2016 To date, information on plasmid analysis in Pandoraea spp. is scarce. To address the gap of knowledge on this, the complete sequences of eight plasmids from Pandoraea spp.
Delicia Yong +3 more
doaj +1 more source
Molecular target of enteric VapC toxins and regulation of vapBC transcription by conditional cooperativity [PDF]
, 2011 The uibiquitous Type II toxin – antitoxin (TA) loci encode two proteins, a toxin and an antitoxin. The antitoxin combines with and neutralizes a cognate toxin. Usually, the TA genes form an operon that is transcribed by a single promoter located upstream
Kristoffer Skovbo Winther +1 more
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