Results 51 to 60 of about 756 (133)

VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity. [PDF]

PLoS ONE, 2018
The chromosome of Mycobacterium tuberculosis (Mtb) contains a large number of Type II toxin-antitoxin (TA) systems. The majority of these belong to the VapBC TA family, characterised by the VapC protein consisting of a PIN domain with four conserved ...
Abigail Sharrock, Alaine Ruthe, Emma S V Andrews, Vickery A Arcus, Joanna L Hicks   +4 more
doaj   +1 more source

Recent Advancements in Toxin and Antitoxin Systems Involved in Bacterial Programmed Cell Death

International Journal of Microbiology, Volume 2010, Issue 1, 2010., 2010
Programmed cell death (PCD) systems have been extensively studied for their significant role in a variety of biological processes in eukaryotic organisms. Recently, more and more researches have revealed the existence of similar systems employed by bacteria in response to various environmental stresses.
Ming-xi Hu, Xiao Zhang, Er-li Li, Yong-Jun Feng, Ingolf Figved Nes   +4 more
wiley   +1 more source

Crystal Structure of VapBC-1 from Nontypeable Haemophilus influenzae and the Effect of PIN Domain Mutations on Survival during Infection

Journal of Bacteriology, 2019
Herein the crystal structure of the VapBC-1 complex from nontypeable Haemophilus influenzae (NTHi) is described. Our results show that some of the mutations in the PIN domain of the VapC-1 toxin were associated with decreased toxicity in E. coli, but the
A. L. Molinaro, M. Kashipathy, S. Lovell, K. Battaile, N. Coussens, M. Shen, D. Daines   +6 more
semanticscholar   +1 more source

VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

Frontiers in Microbiology, 2020
The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma, Gopinath Chattopadhyay, Pankaj Chopra, Munmun Bhasin, Chandrani Thakur, Sakshi Agarwal, Shahbaz Ahmed, Nagasuma Chandra, Raghavan Varadarajan, Raghavan Varadarajan, Ramandeep Singh   +10 more
doaj   +1 more source

Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin–Antitoxin Systems

Toxins, 2020
Mycobacterium tuberculosis genome encodes over 80 toxin–antitoxin (TA) systems. While each toxin interacts with its cognate antitoxin, the abundance of TA systems presents an opportunity for potential non-cognate interactions. TA systems mediate manifold
Himani Tandon, Akhila Melarkode Vattekatte, Narayanaswamy Srinivasan, Sankaran Sandhya   +3 more
doaj   +1 more source

Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin

mBio, 2023
A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis, Daniel J. Willard, Mohamad J. H. Manesh, Shamphavi Sivabalasarma, Sonja-Verena Albers, Robert M. Kelly   +5 more
doaj   +1 more source

High‐quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures

MicrobiologyOpen, Volume 13, Issue 5, October 2024.
In this study, the genome of a new thermophilic cyanobacterium, Thermosynechococcaceae cyanobacterium sp. Okahandja, isolated from a hot spring near Okahandja in Namibia, was sequenced. Additionally, cultivations were conducted at elevated temperatures of 40, 50, and 55°C, followed by analyses of the respective adapted proteomes based on the annotated ...
Nathanael D. Arnold, Michael Paper, Tobias Fuchs, Nadim Ahmad, Patrick Jung, Michael Lakatos, Katia Rodewald, Bernhard Rieger, Farah Qoura, Martha Kandawa‐Schulz, Norbert Mehlmer, Thomas B. Brück   +11 more
wiley   +1 more source

Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. [PDF]

PLoS Genetics, 2017
Acquisition of a single copy, large virulence plasmid, pINV, led to the emergence of Shigella spp. from Escherichia coli. The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial ...
Giulia Pilla, Gareth McVicker, Christoph M Tang   +2 more
doaj   +1 more source

Toxins VapC and PasB from Prokaryotic TA Modules Remain Active in Mammalian Cancer Cells

Toxins, 2014
Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine.
Łukasz Wieteska, Aleksander Skulimowski, Magdalena Cybula, Janusz Szemraj   +3 more
doaj   +1 more source

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis.

The Journal of biological chemistry, 2009
In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis.
Linda, Miallau, Michael, Faller, Janet, Chiang, Mark, Arbing, Feng, Guo, Duilio, Cascio, David, Eisenberg   +6 more
openaire   +1 more source