Results 51 to 60 of about 724 (156)
When Ribonucleases Come into Play in Pathogens: A Survey of Gram‐Positive Bacteria
International Journal of Microbiology, Volume 2012, Issue 1, 2012., 2012 It is widely acknowledged that RNA stability plays critical roles in bacterial adaptation and survival in different environments like those encountered when bacteria infect a host. Bacterial ribonucleases acting alone or in concert with regulatory RNAs or RNA binding proteins are the mediators of the regulatory outcome on RNA stability.
Brian C. Jester +3 more
wiley +1 more source
VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity. [PDF]
PLoS ONE, 2018 The chromosome of Mycobacterium tuberculosis (Mtb) contains a large number of Type II toxin-antitoxin (TA) systems. The majority of these belong to the VapBC TA family, characterised by the VapC protein consisting of a PIN domain with four conserved ...
Abigail Sharrock +4 more
doaj +1 more source
Recent Advancements in Toxin and Antitoxin Systems Involved in Bacterial Programmed Cell Death
International Journal of Microbiology, Volume 2010, Issue 1, 2010., 2010 Programmed cell death (PCD) systems have been extensively studied for their significant role in a variety of biological processes in eukaryotic organisms. Recently, more and more researches have revealed the existence of similar systems employed by bacteria in response to various environmental stresses.
Ming-xi Hu +4 more
wiley +1 more source
The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Frontiers in Microbiology, 2016 Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
doaj +1 more source
VapBC-1 specifically interacts with the vapB-1 TIR. [PDF]
, 2013 (A) The sequence of the 50TIR is shown with arrows indicating the inverted repeat regions and bases above and below the sequence indicating the position of the G to C and T to G substitutions in the TG50TIR and 2M50TIR substrates (see Table 3). Gel shift
Sehresh Saleem (329519) +2 more
core +1 more source
Role of vapBC toxin–antitoxin loci in the thermal stress response of Sulfolobus solfataricus
Biochemical Society Transactions, 2009 TA (toxin–antitoxin) loci are ubiquitous in prokaryotic micro-organisms, including archaea, yet their physiological function is largely unknown. For example, preliminary reports have suggested that TA loci are microbial stress-response elements, although it was recently shown that knocking out all known chromosomally located TA loci in Escherichia coli
Charlotte R, Cooper +4 more
openaire +3 more sources
Fis, VapC-1 and VapBC-1 bind the vapB-1 TIR. [PDF]
, 2013 (A) The sequence of the 50TIR indicating the putative Fis binding site (underline) and the inverted repeat regions (arrows). (B) Gel shift products from samples containing 50TIR alone (lane 1) and 10, 30, 150 or 600 molar ratios of Fis to DNA.
Sehresh Saleem (329519) +2 more
core +1 more source
Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +1 more source
Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin–Antitoxin Systems
Toxins, 2020 Mycobacterium tuberculosis genome encodes over 80 toxin–antitoxin (TA) systems. While each toxin interacts with its cognate antitoxin, the abundance of TA systems presents an opportunity for potential non-cognate interactions. TA systems mediate manifold
Himani Tandon +3 more
doaj +1 more source
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis +5 more
doaj +1 more source