Results 51 to 60 of about 721 (155)
The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Frontiers in Microbiology, 2016 Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
doaj +1 more source
Role of vapBC toxin–antitoxin loci in the thermal stress response of Sulfolobus solfataricus
Biochemical Society Transactions, 2009 TA (toxin–antitoxin) loci are ubiquitous in prokaryotic micro-organisms, including archaea, yet their physiological function is largely unknown. For example, preliminary reports have suggested that TA loci are microbial stress-response elements, although it was recently shown that knocking out all known chromosomally located TA loci in Escherichia coli
Charlotte R, Cooper +4 more
openaire +3 more sources
Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +1 more source
Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin–Antitoxin Systems
Toxins, 2020 Mycobacterium tuberculosis genome encodes over 80 toxin–antitoxin (TA) systems. While each toxin interacts with its cognate antitoxin, the abundance of TA systems presents an opportunity for potential non-cognate interactions. TA systems mediate manifold
Himani Tandon +3 more
doaj +1 more source
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis +5 more
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VapBC systems characterised in this study.
, 2018 Conserved domains and homologous VapB proteins were identified by homology searches using pBLAST. Predicted molecular weights (MWs) of VapBC heterodimers were calculated by ProtParam [28].
Joanna L. Hicks (5706827) +4 more
core +1 more source
Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. [PDF]
PLoS Genetics, 2017 Acquisition of a single copy, large virulence plasmid, pINV, led to the emergence of Shigella spp. from Escherichia coli. The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial ...
Giulia Pilla +2 more
doaj +1 more source
Expression from the NTHi vapBC-1 promoter.
, 2013 β-galactosidase activity indicating lacZ expression under vapBC-1 promoter control in wild type R2866 (diamonds), and R2866 mutants, Δfis (squares), ΔvapBC-1 (crosses), and Δfis ΔvapBC-1 (triangles), was measured every 30 minutes for 2 hours after ...
Sehresh Saleem (329519) +2 more
core +1 more source
Toxins VapC and PasB from Prokaryotic TA Modules Remain Active in Mammalian Cancer Cells
Toxins, 2014 Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine.
Łukasz Wieteska +3 more
doaj +1 more source
Model for the regulation of the vapBC-1 locus.
, 2013 (A) During colonization under favourable conditions, the VapBC-1 complex binds to and autorepresses TA operon transcription. (B) Stress induces Lon and Clp proteases that degrade VapB-1, releasing active VapC-1 toxin.
Sehresh Saleem (329519) +2 more
core +1 more source