Results 31 to 40 of about 721 (155)

The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system

Molecular Microbiology, Volume 118, Issue 6, Page 744-764, December 2022., 2022
Coxiella burnetii is an obligate intracellular bacterium and causative agent of Q fever. Here we report that the C. burnetii genome encodes 11 toxin–antitoxin systems, which is highly unusual for intracellular bacteria, and that one TA system is encoded on the large endogenous plasmid found in almost all C. burnetii isolates.
Shaun Wachter, Diane C. Cockrell, Heather E. Miller, Kimmo Virtaneva, Kishore Kanakabandi, Benjamin Darwitz, Robert A. Heinzen, Paul A. Beare   +7 more
wiley   +1 more source

RepC_soli: a novel promiscuous plasmid type of Rhodobacteraceae mediates horizontal transfer of antibiotic resistances in the ocean

Environmental Microbiology, Volume 23, Issue 9, Page 5395-5411, September 2021., 2021
Summary Alphaproteobacteria are typically characterized by a multipartite genome organization with a chromosome, stable chromids and accessory plasmids. Extrachromosomal elements determine the lifestyle of roseobacters and their horizontal transfer was previously correlated with rapid adaptations to novel ecological niches.
Lukas Birmes, Heike M. Freese, Jörn Petersen   +2 more
wiley   +1 more source

tRNA^fMet Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets. [PDF]

Antimicrob Agents Chemother, 2022
The Mycobacterium tuberculosis genome contains an abundance of toxin-antitoxin (TA) systems, 50 of which belong to the VapBC family. The activity of VapC toxins is controlled by dynamic association with their cognate antitoxins—the toxin is inactive when complexed with VapB antitoxin but active when freed.
Chauhan U, Barth VC, Woychik NA.
europepmc   +3 more sources

Legume–rhizobium dance: an agricultural tool that could be improved?

Microbial Biotechnology, Volume 14, Issue 5, Page 1897-1917, September 2021., 2021
The present review describes the mechanisms involved in the regulation of the entire legume‐rhizobium symbiotic process and the strategies and tools of bacteria for reaching the nitrogen‐fixing state inside the nodule. Also, we revised different approaches to improve the nodulation process for a better crop yield.
Laura A. Basile, Viviana C. Lepek
wiley   +1 more source

Prokaryote toxin–antitoxin modules: Complex regulation of an unclear function

Protein Science, Volume 30, Issue 6, Page 1103-1113, June 2021., 2021
Abstract Toxin–antitoxin (TA) modules are small operons in bacteria and archaea that encode a metabolic inhibitor (toxin) and a matching regulatory protein (antitoxin). While their biochemical activities are often well defined, their biological functions remain unclear. In Type II TA modules, the most common class, both toxin and antitoxin are proteins,
Pieter De Bruyn, Yana Girardin, Remy Loris   +2 more
wiley   +1 more source

Structure‐based design of peptides that trigger Streptococcus pneumoniae cell death

The FEBS Journal, Volume 288, Issue 5, Page 1546-1564, March 2021., 2021
HigBA complex shows a crossed‐scissor interface with two intermolecular β‐sheets at both the N and C termini of the HigA antitoxin. The crossed‐scissor constitutes a new type of interface between HigB and HigA. We report a unique structure of the Streptococcus pneumoniae HigBA system and a novel antimicrobial agent that activates HigB toxin, which ...
Sung‐Min Kang, Chenglong Jin, Do‐Hee Kim, Sung Jean Park, Sang‐Woo Han, Bong‐Jin Lee   +5 more
wiley   +1 more source

Crystal structure of proteolyzed VapBC and DNA‐bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca ²⁺ ‐dependent ribonuclease [PDF]

The FASEB Journal, 2019
Abstract Bacterial toxin‐antitoxin (TA) system has gained attention for its essential roles in cellular maintenance and survival under harsh environmental conditions such as nutrient deficiency and antibiotic treatment. There are at least 14 TA systems in Salmonella enterica
DongWon, Park, Hye-Jin, Yoon, Ki-Young, Lee, Sung-Jean, Park, Seung-Ho, Cheon, Hyung Ho, Lee, Sang Jae, Lee, Bong-Jin, Lee   +7 more
openaire   +2 more sources

Identification of a VapBC toxin–antitoxin system in a thermophilic bacterium Thermus thermophilus HB27 [PDF]

Extremophiles, 2016
There are 12 putative toxin-antitoxin (TA) loci in the Thermus thermophilus HB27 genome, including four VapBC and three HicBA families. Expression of these seven putative toxin genes in Escherichia coli demonstrated that one putative VapC toxin TTC0125 and two putative HicA toxins, TTC1395 and TTC1705, inhibited cell growth, and co-expression with ...
Yuqi, Fan, Takayuki, Hoshino, Akira, Nakamura   +2 more
openaire   +2 more sources

Interplay between transcriptional regulators and VapBC toxin-antitoxin loci during thermal stress response in extremely thermoacidophilic archaea. [PDF]

Environ Microbiol, 2023
Abstract Thermoacidophilic archaea lack sigma factors and the large inventory of heat shock proteins (HSPs) widespread in bacterial genomes, suggesting other strategies for handling thermal stress are involved. Heat shock transcriptomes for the thermoacidophilic archaeon Saccharolobus
Cooper CR, Lewis AM, Notey JS, Mukherjee A, Willard DJ, Blum PH, Kelly RM.   +6 more
europepmc   +3 more sources

Isolation of persister cells within the biofilm and relative gene expression analysis of type II toxin/antitoxin system in Pseudomonas aeruginosa isolates in exponential and stationary phases

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Chronic infections and treatment failure are concerning issues in patients with Pseudomonas aeruginosa infections. Persister cell formation in biofilm is considered a key reason for antibiotic resistance and treatment failure.
Rezvan Golmoradi Zadeh, Behrooz Sadeghi Kalani, Marzie Mahdizade Ari, Malihe Talebi, Shabnam Razavi, Faramarz Masjedian Jazi   +5 more
doaj   +1 more source