Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
Apoptosis like symptoms associated with abortive infection of Mycobacterium smegmatis by mycobacteriophage D29. [PDF]
PLoS ONE, 2022 Mycobacteriophages are phages that infect mycobacteria resulting in their killing. Although lysis is the primary mechanism by which mycobacteriophages cause cell death, others such as abortive infection may also be involved.
Fatema Calcuttawala +5 more
doaj +2 more sources
The Crystal Structure of the Rv0301-Rv0300 VapBC-3 Toxin—Antitoxin Complex From M. Tuberculosis Reveals a Mg2+ Ion in the Active Site and a Putative RNA-Binding Site [PDF]
Protein Science, 2012 AbstractVapBC pairs account for 45 out of 88 identified toxin‐antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the metabolism of the cell, which in the case of VapC toxins is via their RNase activity.
Duilio Cascio +2 more
exaly +4 more sources
Transcriptome profiling of Nudix hydrolase gene deletions in the thermoacidophilic archaeon Sulfolobus acidocaldarius [PDF]
Frontiers in Microbiology, 2023 Nudix hydrolases comprise a large and ubiquitous protein superfamily that catalyzes the hydrolysis of a nucleoside diphosphate linked to another moiety X (Nudix).
Ruth Breuer +5 more
doaj +2 more sources
Insights into toxin-antitoxin systems in the genus Bifidobacterium [PDF]
Applied and Environmental MicrobiologyToxin-antitoxin (TA) systems are widespread genetic modules in prokaryotes, implicated in diverse functions including stress adaptation, genome stability, and virulence.
Claudia Lefimil, Paula Bustamante
doaj +2 more sources
bioRxivShigella flexneri is a facultative intracellular pathogen that causes bacillary dysentery by invading and replicating within intestinal epithelial cells.
E. Saifi +8 more
semanticscholar +2 more sources
Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems [PDF]
Journal of Biological Chemistry, 2009 In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis.
L. Miallau +6 more
semanticscholar +2 more sources
Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis [PDF]
Communications BiologyThe expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26 TA modules of M. tuberculosis.
Arun Sharma +6 more
doaj +2 more sources
Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation [PDF]
mBioToxin-antitoxin (TA) systems are important for stress adaptation in prokaryotes, including persistence, antibiotic resistance, pathogenicity, and biofilm formation.
Arghya Bhowmick +7 more
doaj +2 more sources
Genomic profiling of Morganella morganii: insights into antibiotic resistance genes, pathogenicity islands, and toxin-antitoxin systems [PDF]
Microbiology SpectrumMorganella morganii is an opportunistic pathogen affecting immunocompromised and hospitalized intensive care patients. It colonizes diverse environments and exhibits multidrug resistance.
Tosin Yetunde Senbadejo +2 more
doaj +2 more sources