The crystal structure of the Rv0301‐Rv0300 VapBC‐3 toxin—antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA‐binding site [PDF]
Protein Science, 2012 AbstractVapBC pairs account for 45 out of 88 identified toxin‐antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the metabolism of the cell, which in the case of VapC toxins is via their RNase activity.
Andrew B. Min +5 more
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DNase I protection of the vapBC-1 locus control region by Fis and Vap proteins. [PDF]
, 2013 (A) The 32P-labeled sense strand of 153 bp DNA substrate containing vapB-1 TIR and upstream sequence in the vapBC-1 locus control region, is shown with numbers indicating the distance from the 5′-labeled end.
Sehresh Saleem (329519) +2 more
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Toxins, 2016 Toxin-antitoxin (TA) systems are small genetic elements that are ubiquitous in prokaryotes. Most studies on TA systems have focused on commensal and pathogenic bacteria; yet very few studies have focused on TAs in marine bacteria, especially those ...
Yunxue Guo +4 more
doaj +1 more source
Molecular Biology of Archaea Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus [PDF]
, 2020 TA (toxin-antitoxin) loci are ubiquitous in prokaryotic micro-organisms, including archaea, yet their physiological function is largely unknown. For example, preliminary reports have suggested that TA loci are microbial stress-response elements, although
Sabrina Tachdjian +4 more
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Frontiers in Microbiology, 2015 -Objectives:Previously 14 conjugative plasmids from multi-drug resistant (MDR) Escherichia coli from healthy humans and food-producing animals in Switzerland were sequenced.
JUAN eWANG +5 more
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Bioinformatics analysis of loci vapBC of the cyanobacteria Microcystis aeruginosa PCC 7806 and experimental characterization of putative toxins VapC29, VapC33 and VapC45 [PDF]
, 2022 Sistemi toksin-antitoksin (TA) so sestavljeni iz dveh komponent. Toksin je praviloma stabilen protein, ki v celicah, kjer se izraža, deluje citostatično ali citotoksično, antitoksin pa je nestabilen protein ali RNA, ki preprečuje delovanje toksina in ...
Imperl, Jernej
core
Frontiers in Microbiology, 2016 To date, information on plasmid analysis in Pandoraea spp. is scarce. To address the gap of knowledge on this, the complete sequences of eight plasmids from Pandoraea spp.
Delicia Yong +3 more
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Molecular target of enteric VapC toxins and regulation of vapBC transcription by conditional cooperativity [PDF]
, 2011 The uibiquitous Type II toxin – antitoxin (TA) loci encode two proteins, a toxin and an antitoxin. The antitoxin combines with and neutralizes a cognate toxin. Usually, the TA genes form an operon that is transcribed by a single promoter located upstream
Kristoffer Skovbo Winther +1 more
core
살모넬라균 유래 VapBC 와 SehAB 독소-항독소 단백질의 구조적, 기능적 연구 [PDF]
, 2020 학위논문(박사)--서울대학교 대학원 :약학대학 약학과,2020. 2. 이봉진.세균성의 독소-항독소 시스템은 영양부족, 항생제 처리, 산화스트레스 등의 세포가 힘든 환경에 처했을 때 세포의 유지에 필수적인 역할을 하는 것으로 알려져 주목받고 있다. 독소-항독소 시스템은 항독소의 독소 저해 방식 혹은 항독소의 형태에 따라 6가지 독소-항독소 시스템이 존재한다. 그 중에서 타입 2 독소-항독소 시스템은 가장 많이 연구가 진행되었다.
박동원
core
Cloning, expression and purification of proteins, vaccine candidates from Leptospira interrogans sorovar Copenhageni. Evaluation of immunogenic and functional characteristics. [PDF]
, 2009 A leptospirose é uma zoonose mundial causada por bactéria do gênero Leptospira. O desenvolvimento de uma vacina de subunidade eficaz seria de grande interesse em saúde pública.
Luana Melo Lopes, Lopes, Luana Melo
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