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Toxin–Antitoxin Modules: Genetic Elements with Many Faces and Functions
BacteriaToxin–antitoxin (TA) modules represent sophisticated regulatory networks that have evolved from simple plasmid maintenance factors into multifunctional genetic modules orchestrating bacterial stress responses, pathogenesis, and ecological adaptation ...
Aayush Bahl +5 more
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Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems [PDF]
Journal of Biological Chemistry, 2009 Linda Miallau +6 more
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Abstract Shigella flexneri is a facultative intracellular pathogen that causes bacillary dysentery by invading and replicating within intestinal epithelial cells. Successful intracellular survival requires the bacterium to balance metabolic adaptation with the sustained expression of virulence ...
Saifi, Estelle +8 more
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Characterization of a Toxin-Antitoxin Locus in Acinetobacter baumannii [PDF]
, 2016 Toxin-antitoxin (TA) systems are mechanisms of survival in many species of bacteria. In nontypeable Haemophilus influenzae (NTHi), the type II TA gene pair vapBC-1 encodes the VapB-1 antitoxin protein and the VapC-1 ribonuclease toxin.
Frost, Michaela
core
Regulation of Metabolism in Mycobacteria and Cyanobacteria [PDF]
, 2016 Bacteria encounter changes in their environment and must adapt to these changes in order to survive. Their ability to adapt is determined by their capacity to efficiently regulate their cellular processes.
Vickers, Chelsea
core
VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease [PDF]
, 2007 Nontypeable Haemophilus influenzae (NTHi) organisms are obligate parasites of the human upper respiratory tract that can exist as commensals or pathogens.
Wu, Mack H +2 more
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A Tale about Shigella: Evolution, Plasmid, and Virulence. [PDF]
Microorganisms, 2023 Haidar-Ahmad N +4 more
europepmc +1 more source
, 2022 Toxin-antitoxin (TA) systems are composed of two components. The toxin is typically a stable protein, which exhibits cytostatic or cytotoxic activity in the cells that express it. The antitoxin is either an unstable protein or RNA, which inhibits the activity of the toxin and therefore enables normal cell growth.
openaire +1 more source
Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems. [PDF]
J Bacteriol, 2022 Martyn JE +6 more
europepmc +1 more source
Virulence plasmid pINV as a genetic signature for <i>Shigella flexneri</i> phylogeny. [PDF]
Microb Genom, 2022 Pilla G, Arcari G, Tang CM, Carattoli A.
europepmc +1 more source