Results 101 to 110 of about 756 (133)

Toxin-antitoxin system gene mutations driving Mycobacterium tuberculosis transmission revealed by whole genome sequencing. [PDF]

Front Microbiol
Hou Y, Li Y, Tao N, Kong X, Li Y, Liu Y, Li H, Wang Z.   +7 more
europepmc   +1 more source

Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain

Whelan R, Cyganek M, Dickins B, Thomas JC, McVicker G.   +4 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Deciphering the Role of VapBC Toxin-Antitoxin Systems in Mycobacterium tuberculosis Stress Adaptation

Future Microbiology
Mycobacterium tuberculosis (Mtb) harbors a high number of Toxin-Antitoxin (TA) systems, wherein half of them belong to virulence associated proteins B and C (VapBC) family that has a characteristic PilT N-terminus domain and ribonuclease activity ...
Renu Chaudhary, Zoozeal Thakur, Promod K Mehta   +2 more
exaly   +4 more sources

Characterization of a Novel Toxin-Antitoxin Module, VapBC, Encoded by Leptospira interrogans Chromosome [PDF]

Cell Research, 2004
Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations.
Chuan Wu, Chun Fu Wu
exaly   +4 more sources

Crystal structure of proteolyzed VapBC and DNA‐bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+‐dependent ribonuclease [PDF]

The FASEB Journal, 2019
Bacterial toxin‐antitoxin (TA) system has gained attention for its essential roles in cellular maintenance and survival under harsh environmental conditions such as nutrient deficiency and antibiotic treatment.
D. Park, H. Yoon, Ki-young Lee, Sung‐Jean Park, Seung-Ho Cheon, H. Lee, Sang Jae Lee, Bong-Jin Lee   +7 more
semanticscholar   +3 more sources

Crystal Structure of the VapBC-15 Complex From Mycobacterium tuberculosis Reveals a Two-Metal Ion Dependent PIN-Domain Ribonuclease and a Variable Mode of Toxin–Antitoxin Assembly

Journal of Structural Biology, 2014
Although PIN (PilT N-terminal)-domain proteins are known to have ribonuclease activity, their specific mechanism of action remains unknown. VapCs form a family of ribonucleases that possess a PIN-domain assembly and are known as toxins. The activities of VapCs are impaired by VapB antitoxins.
Uddipan Das, Vivian Pogenberg, Matthias Wilmanns   +2 more
exaly   +5 more sources

Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, Including the Development of an Inhibitor That Activates VapC.

Journal of Medicinal Chemistry, 2020
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K.
Sung-Min Kang, C. Jin, Do-Hee Kim, Yuno Lee, Bong-Jin Lee   +4 more
semanticscholar   +3 more sources

Transcriptional regulation and functional role of VapBC type II toxin-antitoxin system in Shigella flexneri virulence

Shigella flexneri est un pathogène intracellulaire à Gram négatif et l'agent responsable de la dysenterie bacillaire. Sa capacité à envahir les cellules épithéliales et à se disséminer dans les tissus de l'hôte repose sur l'expression finement régulée ...
E. Saifi
semanticscholar   +2 more sources

Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes.

Sub-cellular biochemistry, 2017
Toxin-antitoxin systems are widespread in the bacterial kingdom, including in pathogenic species, where they allow rapid adaptation to changing environmental conditions through selective inhibition of key cellular processes, such as DNA replication or protein translation.
K. L. Bendtsen, D. E. Brodersen
semanticscholar   +5 more sources