Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor. [PDF]
J Chem Inf Model, 2022 Sun H +9 more
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Characterization of a Toxin-Antitoxin Locus in Acinetobacter baumannii
, 2016 Toxin-antitoxin (TA) systems are mechanisms of survival in many species of bacteria. In nontypeable Haemophilus influenzae (NTHi), the type II TA gene pair vapBC-1 encodes the VapB-1 antitoxin protein and the VapC-1 ribonuclease toxin.
Frost, Michaela
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Regulation of Metabolism in Mycobacteria and Cyanobacteria
, 2016 Bacteria encounter changes in their environment and must adapt to these changes in order to survive. Their ability to adapt is determined by their capacity to efficiently regulate their cellular processes.
Vickers, Chelsea
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Comparative in silico analysis of vapBC3 toxin-antitoxin system in Mycobacterium Bovis and Mycobacterium tuberculosis. [PDF]
Sci RepShafipour M +4 more
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Genome Mining Shows Ubiquitous Presence and Extensive Diversity of Toxin-Antitoxin Systems in Pseudomonas syringae. [PDF]
Front Microbiol, 2021 Kandel PP +5 more
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Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria. [PDF]
Int J Mol SciMaj P, Trylska J.
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VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation [PDF]
The major human pathogen Mycobacterium tubercu-losis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence.
Tree JJ +3 more
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Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in Mycobacterium tuberculosis. [PDF]
J BacteriolMalakar B +4 more
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The parABSm system is involved in megaplasmid partitioning and genome integrity maintenance in Thermus thermophilus. [PDF]
G3 (Bethesda), 2023 Li H, Xu L, Li X.
europepmc +1 more source
Generation of a toxin/antitoxin-based counterselection marker for <i>Chlamydia trachomatis</i>. [PDF]
Infect ImmunSteiner E, D'Spain S, Ende R, Derré I.
europepmc +1 more source