PLoS Genetics, 2009 Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M.
Holly R Ramage +2 more
doaj +1 more source
Analysis of the role of VapBC-type toxin-antitoxin modules in growth, stress tolerance and drug tolerance in mycobacteria [PDF]
, 2011 Forty seven of the toxin-antitoxin modules in the genome of Mycobacterium tuberculosis belong to the VapBC family in which the VapC toxin is a member of the PIN-domain protein family associated with nuclease activity.
Ahidjo, Bintou Ahmadou
core
The effect of VapC29 overexpression on the growth and viability of M. smegmatis mc2155 and ΔvapBC strains. [PDF]
, 2018 The effect of conditionally expressing VapC29, VapBC29 or empty vector (EV) on growth (a) and cell viability (b) was examined in a wild-type and vapBC knockout strain of M. smegmatis mc2155.
Joanna L. Hicks (5706827) +4 more
core +1 more source
Les systèmes Toxine-Antitoxine VapBC : des régulateurs de la symbiose fixatrice d'azote Rhizobium-Légumineuse [PDF]
, 2020 During the nitrogen-fixing symbiosis between the model legume Medicago truncatula and the rhizobiaceae Sinorhizobium meliloti, bacteria, differentiated into bacteroids within the nodule, reduce atmospheric nitrogen (N2) into ammonia (NH3), directly ...
Syska, Camille
core
Characterization of PIN-domain Toxin-antitoxins VapBC from Mycobacterium tuberculosis [PDF]
, 2015 Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and Biophysics, 2015.Bacterial toxin-antitoxin systems play important roles in plasmid inheritance, cellular adaptation to stress, the formation of persister ...
Butler, J. Scott, Jin, Guangze
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Investigation of possible tolerance mutations in a VapBC toxin–antitoxin system through structure determination [PDF]
Acta Crystallographica Section A Foundations and Advances, 2021 Maria Raadkjær Nielsen +1 more
openaire +1 more source
BMC Genomics, 2019 Background Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis Complex (MTBC), is capable of infecting several host species, including humans.
Taiana T. Silva-Pereira +7 more
doaj +1 more source
Five Mtb VapC proteins display the same sequence specificity against 924 Pentaprobe RNA. [PDF]
, 2018 The ribonuclease activity of VapC1, 19, 27, 29 & 39 (2.9 μM) was tested against the 924 pentaprobe RNA (18 μM). Negative controls included no VapC (RNA only) at the beginning (RNA only 0) and end (RNA only 60) of the assay reaction, addition of EDTA, and
Joanna L. Hicks (5706827) +4 more
core +1 more source
Functional Genomics of Stress Response in the Hyperthermophilic Crenarchaeon Sufolobus solfataricus and Role of vapBC Toxin-Antitoxin Loci in RNA Management. [PDF]
, 2008 Functional genomics tools were used to examine the dynamic stress response of the hyperthermophile Sulfolobus solfataricus subjected to thermal and pH shifts relative to growth under normal conditions.
Tachdjian, Sabrina
core
Competition binding of 50TIR and 50US by Vap proteins. [PDF]
, 2013 Gel shift products from addition of 50US substrate into samples containing 50TIR substrate and either (A) VapBC-1 or (B) VapC-1 at a 150∶1 molar ratio of VapC-1 protein to DNA. VapB-1 and VapC-1 are at a 3∶1 molar ratio in the VapBC-1 samples, but VapC-1∶
Sehresh Saleem (329519) +2 more
core +1 more source