Cyclic adenosine monophosphate, CA++, and membranes. [PDF]
Since the initial discovery of cyclic 3',5'-adenosine monophosphate (3',5'AMP) by Rall, Sutherland, and Berthet' and its role in glycogenolysis in the liver,2 evidence has accumulated indicating that this nucleotide is an intermediate in the action of many peptide hormones.3-9 More recently it has also been implicated in the release of insulin from the
Howard Rasmussen, Alan Tenenhouse
openaire +3 more sources
The effect of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the heat shock protein 90 inhibitor NVP-AUY922 (AUY922) on survival of thyroid carcinoma cells was elucidated. The SW1736 and TPC-1 human thyroid carcinoma cells
Si Hyoung Kim+6 more
doaj +1 more source
Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases [PDF]
Adenosine receptors are G-protein-coupled receptors involved in a wide range of physiological and pathological phenomena in most mammalian systems. All four receptors are widely expressed in the central nervous system, where they modulate neurotransmitter release and neuronal plasticity. A large number of gene association studies have shown that common
arxiv +1 more source
Gastroprotective effects of oral nucleotide administration [PDF]
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A+4 more
core +2 more sources
Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase.
Cordycepin is an efficient component of Cordyceps spp, a traditional Chinese medicine widely used for healthcare in China, and has been recently acted as a strong anticancer agent for clinic.
Feng Huang+4 more
doaj +1 more source
Modelling of Dictyostelium Discoideum Movement in Linear Gradient of Chemoattractant [PDF]
Chemotaxis is a ubiquitous biological phenomenon in which cells detect a spatial gradient of chemoattractant, and then move towards the source. Here we present a position-dependent advection-diffusion model that quantitatively describes the statistical features of the chemotactic motion of the social amoeba {\it Dictyostelium discoideum} in a linear ...
arxiv +1 more source
c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteria [PDF]
Signal transduction pathways enable organisms to monitor their external environment and adjust gene regulation to appropriately modify their cellular processes.
Cho, Kyu Hong+2 more
core +2 more sources
Phosphorus availability regulates intracellular nucleotides in marine eukaryotic phytoplankton
Marine eukaryotic phytoplankton adapt to low phosphorus (P) in the oceans through a variety of stepâwise mechanisms including lipid substitution and decreased nucleic acid content.
Elizabeth B. Kujawinski+6 more
doaj +1 more source
On the parabolic-elliptic Keller-Segel system with signal-dependent motilities: a paradigm for global boundedness and steady states [PDF]
This paper is concerned with a parabolic-elliptic Keller-Segel system where both diffusive and chemotactic coefficients (motility functions) depend on the chemical signal density. This system was originally proposed by Keller and Segel in \cite{KS-1971-JTB2} to describe the aggregation phase of {\it Dictyostelium discoideum} cells in response to the ...
arxiv +1 more source
3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Amy C. M.+27 more
core +1 more source