Results 21 to 30 of about 252,333 (374)
Amyloid precursor protein processing and Alzheimer's disease.
Annual Review of Neuroscience, 2011 Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau.
Richard O'Brien, P. Wong
semanticscholar +1 more source
A unifying framework for amyloid-mediated membrane damage: The lipid-chaperon hypothesis [PDF]
, 2021 Over the past thirty years, researchers have highlighted the role played by a class of proteins or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid Abeta peptide, which is known to form senile plaques in Alzheimer's disease; ii) alpha-synuclein, responsible for Lewy body formation in Parkinson's disease and iii ...
arxiv +1 more source
Coupling enhanced sampling of the apo-receptor with template-based ligand conformers selection: Performance in pose prediction in the D3R-GC4 [PDF]
Journal of Computer-Aided Molecular Design 34, 149-162 (2020), 2020 We report the performance of our newly introduced Ensemble Docking with Enhanced sampling of pocket Shape (EDES) protocol coupled to a template-based algorithm to generate near-native ligand conformations in the 2019 iteration of the Grand Challenge organized by the D3R consortium.
arxiv +1 more source
Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions
Molecules, 2022 The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system ...
Chen Ma, Fenfang Hong, Shulong Yang
doaj +1 more source
Amyloid precursor protein modulates β-catenin degradation
Journal of Neuroinflammation, 2007 Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj +1 more source
Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. [PDF]
PLoS ONE, 2011 BACKGROUND: sAPPα released after α secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function
Stéphanie Chasseigneaux +7 more
doaj +1 more source
Veterinary Sciences, 2023 Amyloid-producing ameloblastoma (APAB) is characterized by abundant amyloid deposits in ameloblastoma, but the amyloid precursor protein is unknown.
Niki Sedghi Masoud +5 more
doaj +1 more source
Amyloid precursor protein in pancreatic islets [PDF]
Journal of Endocrinology, 2017 The amyloid precursor protein (APP) has been extensively investigated for its role in the production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer’s disease (AD). Epidemiological evidence suggests type 2 diabetes is a risk factor for AD. The pancreas is an essential regulator of blood glucose levels through the secretion of the hormones ...
Colin K. Combs +2 more
openaire +3 more sources
An optimization strategy on prion AGAAAAGA amyloid fibril molecular modeling [PDF]
Central European Journal of Bioliogy (2012) DOI:
10.2478/s11535-011-0088-7, 2010 X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy are two powerful tools to determine the protein 3D structure. However, not all proteins can be successfully crystallized, particularly for membrane proteins. Although NMR spectroscopy is indeed very powerful in determining the 3D structures of membrane proteins, same as X-ray ...
arxiv +2 more sources
PLoS ONE, 2016 The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a ...
Isobel J Whitehouse +7 more
doaj +1 more source