Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis
Frontiers in Cellular and Infection Microbiology, 2023 Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein +5 more
doaj +1 more source
Profil Terapi Penggunaan Obat BPH (Benign Prostatic Hyperplasia) Tamsulosin dengan Dutasteride pada Pasien Pembesaran Prostat Jinak [PDF]
, 2023 Background: Benign Prostatic Hyperplasia (BPH) is a term for hyperplasia and hyperplasia. stromal cells prostate gland epithelium. Basically, BPH grows in men who are old and have testes that still produce testosterone.
Iin Ruliana Rohenti +2 more
core +2 more sources
Drug Combinations in Breast Cancer Therapy [PDF]
Pharmaceutical Nanotechnology, 2019 Breast cancer therapy involves a multidisciplinary approach comprising surgery, radiotherapy, neoadjuvant and adjuvant therapy. Effective therapy of breast cancer requires maximum therapeutic efficacy, with minimal undesirable effects to ensure a good quality of life for patients.
Funmilola A. Fisusi, Emmanuel O. Akala
openaire +3 more sources
Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
core +6 more sources
Open Journal of Psychiatry and Allied Sciences, 2016 Objective: To study the prescribing pattern of antipsychotic drugs in the outpatient department of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam.
Pinaki Chakravarty +2 more
doaj +1 more source
Recent Advances in Curcumin-Based Combination Nanomedicines for Cancer Therapy
Journal of Functional Biomaterials, 2023 Standard cancer chemotherapeutics often produce significant adverse effects and eventually lose their effectiveness due to the emergence of resistance mechanisms.
Amir R. Afshari +3 more
doaj +1 more source
Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]
, 2014 Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L. +4 more
core +3 more sources
iTReX: Interactive exploration of mono- and combination therapy dose response profiling data [PDF]
, 2021 High throughput screening methods, measuring the sensitivity and resistance of tumor cells to drug treatments have been rapidly evolving. Not only do these screens allow correlating response profiles to tumor genomic features for developing novel ...
Berker, Yannick +12 more
core +2 more sources
Machine learning approaches for drug combination therapies [PDF]
Briefings in Bioinformatics, 2021 AbstractDrug combination therapy is a promising strategy to treat complex diseases such as cancer and infectious diseases. However, current knowledge of drug combination therapies, especially in cancer patients, is limited because of adverse drug effects, toxicity and cell line heterogeneity. Screening new drug combinations requires substantial efforts
Betul Guvenc Paltun +7 more
openaire +4 more sources
Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]
, 2015 Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric +14 more
core +2 more sources