Results 21 to 30 of about 2,013 (172)
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. [PDF]
Bioessays, 2023 We hypothesize that tissues exist naturally in a heme‐deficient condition that limits the heme content and functions of heme proteins. The nitric oxide (NO) that is made in our tissues can control cell heme availability in a bimodal way, and so regulate heme protein functions in health and disease.
Stuehr DJ +5 more
europepmc +2 more sources
Theoretical Study on the Effective Magnetic Moments of Some Hemeproteins [PDF]
Progress of Theoretical Physics Supplement, 1961 It is pointed out that the measurement of the static magnetic susceptibilities over a wide temperature range will be able to the detailed information about the electronic structure of the paramagnetic heme derivatives. On the basis of the data given by the electron paramagnetic resonance experiment, formulas for the temperature dependence of the ...
Masao Kotani
openaire +3 more sources
Biomedicines, 2022 The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to ...
Diego A. Bonilla +9 more
doaj +1 more source
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell +4 more
wiley +2 more sources
Chemoselective Caging of Carboxyl Groups for On‐Demand Protein Activation with Small Molecules
Angewandte Chemie, Volume 135, Issue 22, May 22, 2023., 2023 The caging of amino acid side chains can provide exquisite control of protein function. The first chemical caging of carboxyl groups (Asp and Glu) in enzymic active sites is reported. Caging of a heme propionate in a protein was also feasible by this approach based on esterification with a tuned diazo compound.
Yana D. Petri +2 more
wiley +2 more sources
Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter
Antioxidants, 2022 Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory,
Jianyun Liu +7 more
doaj +1 more source
Antioxidants, 2022 Nitrobindins (Nbs) are all-β-barrel heme proteins and are present in prokaryotes and eukaryotes. Although their function(s) is still obscure, Nbs trap NO and inactivate peroxynitrite.
Giovanna De Simone +4 more
doaj +1 more source
Recent Approaches for Manipulating Globin Gene Expression in Treating Hemoglobinopathies
Frontiers in Genome Editing, 2021 Tissue oxygenation throughout life depends on the activity of hemoglobin (Hb) one of the hemeproteins that binds oxygen in the lungs and secures its delivery throughout the body.
Claudio Mussolino +2 more
doaj +1 more source
Rhabdomyolysis as cause, consequence, or mimicker of myocardial infarction: A case report
Clinical Case Reports, Volume 11, Issue 11, November 2023., 2023 Key Clinical Message A timely diagnosis is essential to start appropriate therapy and to reduce risks of life‐threatening complications of rhabdomyolysis. Some cases can undergo differential diagnosis with other clinical conditions, e.g., myocardial infarction.
Marina Nasello +11 more
wiley +1 more source
Advanced Science, Volume 10, Issue 29, October 17, 2023., 2023 This study focuses on the molecular action of two histone chaperones: SET/template‐activating factor‐Iβ and nucleophosmin 1. It is shown how these chaperones have specificity for fully dismantled nucleosomes, characterized the histone eviction (removal) process, and its modulation by cytochrome c.
Pedro Buzón +5 more
wiley +1 more source