Results 21 to 30 of about 92,583 (117)

Lone Pair…π Contacts and Structure Signatures of r(UNCG) Tetraloops, Z-Turns, and Z-Steps: A WebFR3D Survey

Molecules, 2022
Z-DNA and Z-RNA have long appeared as oddities to nucleic acid scientists. However, their Z-step constituents are recurrently observed in all types of nucleic acid systems including ribosomes.
Craig L. Zirbel, Pascal Auffinger
doaj   +1 more source

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability

ChemistryOpen, 2022
Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers selected for specific binding functions and have potential applications in medicine and biotechnology.
Elaina P. Boyle, Dr. Levan Lomidze, Prof. Dr. Karin Musier‐Forsyth, Prof. Dr. Besik Kankia   +3 more
doaj   +1 more source

Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. [PDF]

PLoS ONE, 2014
ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial pathogen Chlamydia trachomatis. Despite structural homology within both receiver and effector domains
Michael L Barta, John M Hickey, Asokan Anbanandam, Kevin Dyer, Michal Hammel, P Scott Hefty   +5 more
doaj   +1 more source

Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids

Nanomaterials, 2022
Spherical nucleic acids (SNAs)—nanostructures, consisting of a nanoparticle core densely functionalized with a shell of short oligonucleotide strands—are a rapidly emerging class of nanoparticle-based therapeutics with unique properties and specific ...
Erik Dimitrov, Natalia Toncheva-Moncheva, Pavel Bakardzhiev, Aleksander Forys, Jordan Doumanov, Kirilka Mladenova, Svetla Petrova, Barbara Trzebicka, Stanislav Rangelov   +8 more
doaj   +1 more source

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Molecules, 2021
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto   +5 more
doaj   +1 more source

Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

Journal of Nucleic Acids, 2012
“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability.
Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste   +6 more
doaj   +1 more source

The Many (Inter)faces of Anti-CRISPRs: Modulation of CRISPR-Cas Structure and Dynamics by Mechanistically Diverse Inhibitors

Biomolecules, 2023
The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs), has enabled the development of highly controllable and precise CRISPR-Cas tools.
Helen B. Belato, George P. Lisi
doaj   +1 more source

Small-Angle Scattering as a Structural Probe for Nucleic Acid Nanoparticles (NANPs) in a Dynamic Solution Environment

Nanomaterials, 2019
Nucleic acid-based technologies are an emerging research focus area for pharmacological and biological studies because they are biocompatible and can be designed to produce a variety of scaffolds at the nanometer scale.
Ryan C. Oliver, Lewis A. Rolband, Alanna M. Hutchinson-Lundy, Kirill A. Afonin, Joanna K. Krueger   +4 more
doaj   +1 more source

Pyrrolidine nucleotide analogs with a tunable conformation

Beilstein Journal of Organic Chemistry, 2014
Conformational preferences of the pyrrolidine ring in nucleotide analogs 7–14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the ...
Lenka Poštová Slavětínská, Dominik Rejman, Radek Pohl   +2 more
doaj   +1 more source