Results 21 to 30 of about 193,556 (316)
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
Frontiers in Neuroscience, 2020 Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its physiological functions are only partially understood. α-syn accumulation is associated with Parkinson’s disease, dementia with Lewy bodies, and multiple system ...
Luis D. Bernal-Conde +13 more
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Current Opinion in Cell Biology, 2018 Eukaryotic cells are organized into membrane-bound organelles. These organelles communicate with one another through vesicular trafficking pathways and membrane contact sites (MCSs). MCSs are sites of close apposition between two or more organelles that play diverse roles in the exchange of metabolites, lipids and proteins.
Sarah Cohen +2 more
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Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
Nature Communications, 2018 Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division ...
Yuuta Imoto +7 more
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mSphere, 2022 Genetically encoded tags, such as engineered ascorbate peroxidase APEX2, offer unique advantages for the specific labeling of subcellular structures in electron microscopy (EM).
Hui Li +3 more
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Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
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Evolving a photosynthetic organelle [PDF]
BMC Biology, 2012 The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or chloroplasts, of algae and plants ...
John M. Archibald, Takuro Nakayama
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Cartography of an organelle [PDF]
Nature Methods, 2007 Peptide counting in mass spectrometry allows researchers to draw a quantitative proteomic map of the ER and Golgi.
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A quantitative method to monitor STING degradation with dual-luciferase reporters
Cell Structure and FunctionStimulator of interferon genes (STING) triggers the type I interferon and inflammatory responses against a variety of DNA pathogens, which is essential to limiting viral infection and replication.
Tsumugi Shoji +8 more
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Plastid origin: who, when and why?
Acta Societatis Botanicorum Poloniae, 2014 The origin of plastids is best explained by endosymbiotic theory, which dates back to the early 1900s. Three lines of evidence based on protein import machineries and molecular phylogenies of eukaryote (host) and cyanobacterial (endosymbiont) genes point
Chuan Ku +5 more
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The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
Frontiers in Physiology, 2021 Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in ...
Yucan Dai, Haiqing Tang, Shanshan Pang
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